Regional cerebral blood flow patterns during verbal and nonverbal auditory activation

Current views of the relationship between audition and cerebral function suggest that increases in regional cerebral blood flow (rCBF) would occur in the superior, mid, and posterior portions of the temporal lobes, and that these changes would be more lateralized to the left hemisphere for a verbal than a nonverbal auditory task. We measured rCBF using the xenon inhalation technique in a group of healthy subjects during three conditions: (1) resting baseline, (2) auditory verbal activation (listening for word meaning), and (3) auditory nonverbal activation (listening for reduction of intensity in a series of noise bursts). Both verbal and nonverbal conditions produced highly significant increases in rCBF over the left posterior Sylvian region with a trend for verbal activation to evoke a wider area of flow increase than the nonverbal task.