Regional cerebral blood flow in normal pressure hydrocephalus

Neill R Graff Radford, Karim Rezai, John C. Godersky, Paul Eslinger, Hanna Damasio, Peter T. Kirchner

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Regional cerebral blood flow (rcbf) was studied preoperatively and at 2 and 6 months postoperatively in 22 normal pressure hydrocephalus patients using xenon- 133 inhalation and single photon emission computed tomography. Sixteen of the 22 patients improved (improved group) and six did not (unimproved group). The following comparisons were made: (1) preoperative rcbf in the improved group, to 14 normal elderly volunteers and to that in 59 SDAT (senile dementia of the Alzheimer type) patients; (2) preoperative rcbf in the improved and unimproved groups to determine if rcbf could predict surgical outcome; (3) pre- to postoperative rcbf in the improved group to see if increased cbf accounted for clinical improvement. The findings were: (1) preoperative rcbf in the improved group was lower than that in normal controls but was the same as that in SDAT; however, the ratios of rcbf values in anterior and posterior brain regions were significantly different between improved group and SDAT (p = 002); (2) an anterior/posterior ratio of 105 correctly classified surgical outcome in 19/22 patients; five of six in the unimproved group were above this cut off while 14/16 in the improved group were below; (3) in the improved group rcbf increased at 2 but not at 6 months after surgery without a corresponding reduction of clinical signs, supporting the notion that increase in cbf probably does not account for clinical improvement in normal pressure hydrocephalus.

Original languageEnglish (US)
Pages (from-to)1589-1596
Number of pages8
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume50
Issue number12
DOIs
StatePublished - 1987
Externally publishedYes

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Cerebrovascular Circulation
Normal Pressure Hydrocephalus
Regional Blood Flow
Alzheimer Disease
Xenon
Single-Photon Emission-Computed Tomography
Inhalation
Healthy Volunteers

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Regional cerebral blood flow in normal pressure hydrocephalus. / Graff Radford, Neill R; Rezai, Karim; Godersky, John C.; Eslinger, Paul; Damasio, Hanna; Kirchner, Peter T.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 50, No. 12, 1987, p. 1589-1596.

Research output: Contribution to journalArticle

Graff Radford, Neill R ; Rezai, Karim ; Godersky, John C. ; Eslinger, Paul ; Damasio, Hanna ; Kirchner, Peter T. / Regional cerebral blood flow in normal pressure hydrocephalus. In: Journal of Neurology, Neurosurgery and Psychiatry. 1987 ; Vol. 50, No. 12. pp. 1589-1596.
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