Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

R. J. Mathew; W. H. Wilson; N. Y. Chiu; T. G. Turkington; T. R. Degrado; R. E. Coleman

doi:10.1111/j.1600-0447.1999.tb10916.x

Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

R. J. Mathew, W. H. Wilson, N. Y. Chiu, T. G. Turkington, T. R. Degrado, R. E. Coleman

Radiology

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Objective: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. Method: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. Results: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. Conclusion: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.

Original language	English (US)
Pages (from-to)	67-75
Number of pages	9
Journal	Acta Psychiatrica Scandinavica
Volume	100
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0447.1999.tb10916.x
State	Published - 1999

Keywords

Cerebral blood flow (CBF)
Depersonalization
Positron emission tomography (PET)
Tetrahydrocannabinol (THC)

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1111/j.1600-0447.1999.tb10916.x

Cite this

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abstract = "Objective: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. Method: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. Results: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. Conclusion: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.",

keywords = "Cerebral blood flow (CBF), Depersonalization, Positron emission tomography (PET), Tetrahydrocannabinol (THC)",

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T1 - Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

AU - Mathew, R. J.

AU - Wilson, W. H.

AU - Chiu, N. Y.

AU - Turkington, T. G.

AU - Degrado, T. R.

AU - Coleman, R. E.

PY - 1999

Y1 - 1999

N2 - Objective: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. Method: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. Results: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. Conclusion: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.

AB - Objective: The aim of this study was to examine the relationship between depersonalization induced by tetrahydrocannabinol (THC), and regional brain activation. Method: Cerebral blood flow (CBF) was measured by means of positron emission tomography (PET) in 59 normal right-handed volunteers before and following intravenous infusions of THC. Results: After THC, CBF showed a global increase which was more marked in the right hemisphere, frontal lobes and anterior cingulate. Conclusion: Regression analyses showed positive correlations between the right frontal and anterior cingulate and depersonalization.

KW - Cerebral blood flow (CBF)

KW - Depersonalization

KW - Positron emission tomography (PET)

KW - Tetrahydrocannabinol (THC)

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Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration

Abstract

Keywords

ASJC Scopus subject areas

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