Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction

Shivaram P. Arunachalam, Arvin Arani, Francis Baffour, Joseph A. Rysavy, Phillip J. Rossman, Kevin J. Glaser, David S. Lake, Joshua D. Trzasko, Armando Manduca, Kiaran P. McGee, Richard L. Ehman, Philip A. Araoz

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Purpose: The stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing. Methods: Myocardial infarct was induced in a porcine model by embolizing the left circumflex artery. Fourteen days postinfarction, MRE imaging was performed in diastole using an echocardiogram-gated spin-echo echo-planar-imaging sequence with 140-Hz vibrations and 3D MRE processing. The MRE stiffness and tensile modulus from uniaxial testing were compared between the remote and infarcted myocardium. Results: Myocardial infarcts showed increased in vivo MRE stiffness compared with remote myocardium (4.6 ± 0.7 kPa versus 3.0 ± 0.6 kPa, P = 0.02) within the same pig. Ex vivo uniaxial mechanical testing confirmed the in vivo MRE results, showing that myocardial infarcts were stiffer than remote myocardium (650 ± 80 kPa versus 110 ± 20 kPa, P = 0.01). Conclusions: These results demonstrate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE. Magn Reson Med 79:361–369, 2018.

Original languageEnglish (US)
Pages (from-to)361-369
Number of pages9
JournalMagnetic Resonance in Medicine
Volume79
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • cardiac MRE
  • cardiac elastography
  • heart failure
  • magnetic resonance elastography
  • myocardial infarction
  • myocardial stiffness
  • shear modulus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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