Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction

Shivaram P. Arunachalam; Arvin Arani; Francis Baffour; Joseph A. Rysavy; Phillip J. Rossman; Kevin J. Glaser; David S. Lake; Joshua D. Trzasko; Armando Manduca; Kiaran P. McGee; Richard L. Ehman; Philip A. Araoz

doi:10.1002/mrm.26695

Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction

Shivaram P. Arunachalam, Arvin Arani, Francis Baffour, Joseph A. Rysavy, Phillip J. Rossman, Kevin J. Glaser, David S. Lake, Joshua D. Trzasko, Armando Manduca, Kiaran P. McGee, Richard L. Ehman, Philip A. Araoz

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Purpose: The stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing. Methods: Myocardial infarct was induced in a porcine model by embolizing the left circumflex artery. Fourteen days postinfarction, MRE imaging was performed in diastole using an echocardiogram-gated spin-echo echo-planar-imaging sequence with 140-Hz vibrations and 3D MRE processing. The MRE stiffness and tensile modulus from uniaxial testing were compared between the remote and infarcted myocardium. Results: Myocardial infarcts showed increased in vivo MRE stiffness compared with remote myocardium (4.6 ± 0.7 kPa versus 3.0 ± 0.6 kPa, P = 0.02) within the same pig. Ex vivo uniaxial mechanical testing confirmed the in vivo MRE results, showing that myocardial infarcts were stiffer than remote myocardium (650 ± 80 kPa versus 110 ± 20 kPa, P = 0.01). Conclusions: These results demonstrate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE. Magn Reson Med 79:361–369, 2018.

Original language	English (US)
Pages (from-to)	361-369
Number of pages	9
Journal	Magnetic Resonance in Medicine
Volume	79
Issue number	1
DOIs	https://doi.org/10.1002/mrm.26695
State	Published - Jan 2018

Keywords

cardiac MRE
cardiac elastography
heart failure
magnetic resonance elastography
myocardial infarction
myocardial stiffness
shear modulus

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.26695

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Arunachalam, S. P., Arani, A., Baffour, F., Rysavy, J. A., Rossman, P. J., Glaser, K. J., Lake, D. S., Trzasko, J. D., Manduca, A., McGee, K. P., Ehman, R. L., & Araoz, P. A. (2018). Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction. Magnetic Resonance in Medicine, 79(1), 361-369. https://doi.org/10.1002/mrm.26695

Arunachalam, SP , Arani, A, Baffour, F, Rysavy, JA, Rossman, PJ, Glaser, KJ, Lake, DS, Trzasko, JD , Manduca, A , McGee, KP , Ehman, RL & Araoz, PA 2018, 'Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction', Magnetic Resonance in Medicine, vol. 79, no. 1, pp. 361-369. https://doi.org/10.1002/mrm.26695

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title = "Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction",

abstract = "Purpose: The stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing. Methods: Myocardial infarct was induced in a porcine model by embolizing the left circumflex artery. Fourteen days postinfarction, MRE imaging was performed in diastole using an echocardiogram-gated spin-echo echo-planar-imaging sequence with 140-Hz vibrations and 3D MRE processing. The MRE stiffness and tensile modulus from uniaxial testing were compared between the remote and infarcted myocardium. Results: Myocardial infarcts showed increased in vivo MRE stiffness compared with remote myocardium (4.6 ± 0.7 kPa versus 3.0 ± 0.6 kPa, P = 0.02) within the same pig. Ex vivo uniaxial mechanical testing confirmed the in vivo MRE results, showing that myocardial infarcts were stiffer than remote myocardium (650 ± 80 kPa versus 110 ± 20 kPa, P = 0.01). Conclusions: These results demonstrate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE. Magn Reson Med 79:361–369, 2018.",

keywords = "cardiac MRE, cardiac elastography, heart failure, magnetic resonance elastography, myocardial infarction, myocardial stiffness, shear modulus",

author = "Arunachalam, {Shivaram P.} and Arvin Arani and Francis Baffour and Rysavy, {Joseph A.} and Rossman, {Phillip J.} and Glaser, {Kevin J.} and Lake, {David S.} and Trzasko, {Joshua D.} and Armando Manduca and McGee, {Kiaran P.} and Ehman, {Richard L.} and Araoz, {Philip A.}",

note = "Publisher Copyright: {\textcopyright} 2017 International Society for Magnetic Resonance in Medicine",

year = "2018",

month = jan,

doi = "10.1002/mrm.26695",

language = "English (US)",

volume = "79",

pages = "361--369",

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T1 - Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction

AU - Arunachalam, Shivaram P.

AU - Arani, Arvin

AU - Baffour, Francis

AU - Rysavy, Joseph A.

AU - Rossman, Phillip J.

AU - Glaser, Kevin J.

AU - Lake, David S.

AU - Trzasko, Joshua D.

AU - Manduca, Armando

AU - McGee, Kiaran P.

AU - Ehman, Richard L.

AU - Araoz, Philip A.

PY - 2018/1

Y1 - 2018/1

N2 - Purpose: The stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing. Methods: Myocardial infarct was induced in a porcine model by embolizing the left circumflex artery. Fourteen days postinfarction, MRE imaging was performed in diastole using an echocardiogram-gated spin-echo echo-planar-imaging sequence with 140-Hz vibrations and 3D MRE processing. The MRE stiffness and tensile modulus from uniaxial testing were compared between the remote and infarcted myocardium. Results: Myocardial infarcts showed increased in vivo MRE stiffness compared with remote myocardium (4.6 ± 0.7 kPa versus 3.0 ± 0.6 kPa, P = 0.02) within the same pig. Ex vivo uniaxial mechanical testing confirmed the in vivo MRE results, showing that myocardial infarcts were stiffer than remote myocardium (650 ± 80 kPa versus 110 ± 20 kPa, P = 0.01). Conclusions: These results demonstrate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE. Magn Reson Med 79:361–369, 2018.

AB - Purpose: The stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing. Methods: Myocardial infarct was induced in a porcine model by embolizing the left circumflex artery. Fourteen days postinfarction, MRE imaging was performed in diastole using an echocardiogram-gated spin-echo echo-planar-imaging sequence with 140-Hz vibrations and 3D MRE processing. The MRE stiffness and tensile modulus from uniaxial testing were compared between the remote and infarcted myocardium. Results: Myocardial infarcts showed increased in vivo MRE stiffness compared with remote myocardium (4.6 ± 0.7 kPa versus 3.0 ± 0.6 kPa, P = 0.02) within the same pig. Ex vivo uniaxial mechanical testing confirmed the in vivo MRE results, showing that myocardial infarcts were stiffer than remote myocardium (650 ± 80 kPa versus 110 ± 20 kPa, P = 0.01). Conclusions: These results demonstrate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE. Magn Reson Med 79:361–369, 2018.

KW - cardiac MRE

KW - cardiac elastography

KW - heart failure

KW - magnetic resonance elastography

KW - myocardial infarction

KW - myocardial stiffness

KW - shear modulus

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Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction

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