Regional adaptations of rabbit diaphragm muscle fibers to unilateral denervation

W. Z. Zhan, G. A. Farkas, M. A. Schroeder, L. E. Gosselin, Gary C Sieck

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We hypothesized that adaptations of the rabbit diaphragm (Dia) after unilateral denervation (DNV) result from removal of a neural influence rather than from passive stress. Length changes of midcostal and sternal Dia regions were measured before and after DNV by using sonomicrometry. Midcostal fibers passively lengthened after DNV, whereas sternal fibers shortened. In both regions, these length changes were associated with minimal stress, as estimated from passive force-length relationships. Morphological and contractile adaptions of midcostal and sternal Dia regions were examined after i and 4 wk of DNV. In both Dia regions, type I fibers progressively hypertrophied, whereas type IIb fibers atrophied. After DNV, changes in isometric contraction were similar in both Dia regions. Twitch contraction and half-relaxation times increased, force-frequency relationships shifted leftward, and maximum tetanic force decreased. We conclude that passive length changes and mechanical stress are not the main determinants of the morphological and contractile adaptations of the Dia after unilateral DNV but that these adaptations result from DNV itself.

Original languageEnglish (US)
Pages (from-to)941-950
Number of pages10
JournalJournal of Applied Physiology
Volume79
Issue number3
StatePublished - 1995

Fingerprint

Denervation
Diaphragm
Rabbits
Muscles
Mechanical Stress
Isometric Contraction

Keywords

  • cross-sectional area
  • hemidiaphragm
  • passive stretch
  • sonomicrometry

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Zhan, W. Z., Farkas, G. A., Schroeder, M. A., Gosselin, L. E., & Sieck, G. C. (1995). Regional adaptations of rabbit diaphragm muscle fibers to unilateral denervation. Journal of Applied Physiology, 79(3), 941-950.

Regional adaptations of rabbit diaphragm muscle fibers to unilateral denervation. / Zhan, W. Z.; Farkas, G. A.; Schroeder, M. A.; Gosselin, L. E.; Sieck, Gary C.

In: Journal of Applied Physiology, Vol. 79, No. 3, 1995, p. 941-950.

Research output: Contribution to journalArticle

Zhan, WZ, Farkas, GA, Schroeder, MA, Gosselin, LE & Sieck, GC 1995, 'Regional adaptations of rabbit diaphragm muscle fibers to unilateral denervation', Journal of Applied Physiology, vol. 79, no. 3, pp. 941-950.
Zhan WZ, Farkas GA, Schroeder MA, Gosselin LE, Sieck GC. Regional adaptations of rabbit diaphragm muscle fibers to unilateral denervation. Journal of Applied Physiology. 1995;79(3):941-950.
Zhan, W. Z. ; Farkas, G. A. ; Schroeder, M. A. ; Gosselin, L. E. ; Sieck, Gary C. / Regional adaptations of rabbit diaphragm muscle fibers to unilateral denervation. In: Journal of Applied Physiology. 1995 ; Vol. 79, No. 3. pp. 941-950.
@article{e62eead564cd42f2a254b2fc371580ff,
title = "Regional adaptations of rabbit diaphragm muscle fibers to unilateral denervation",
abstract = "We hypothesized that adaptations of the rabbit diaphragm (Dia) after unilateral denervation (DNV) result from removal of a neural influence rather than from passive stress. Length changes of midcostal and sternal Dia regions were measured before and after DNV by using sonomicrometry. Midcostal fibers passively lengthened after DNV, whereas sternal fibers shortened. In both regions, these length changes were associated with minimal stress, as estimated from passive force-length relationships. Morphological and contractile adaptions of midcostal and sternal Dia regions were examined after i and 4 wk of DNV. In both Dia regions, type I fibers progressively hypertrophied, whereas type IIb fibers atrophied. After DNV, changes in isometric contraction were similar in both Dia regions. Twitch contraction and half-relaxation times increased, force-frequency relationships shifted leftward, and maximum tetanic force decreased. We conclude that passive length changes and mechanical stress are not the main determinants of the morphological and contractile adaptations of the Dia after unilateral DNV but that these adaptations result from DNV itself.",
keywords = "cross-sectional area, hemidiaphragm, passive stretch, sonomicrometry",
author = "Zhan, {W. Z.} and Farkas, {G. A.} and Schroeder, {M. A.} and Gosselin, {L. E.} and Sieck, {Gary C}",
year = "1995",
language = "English (US)",
volume = "79",
pages = "941--950",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

TY - JOUR

T1 - Regional adaptations of rabbit diaphragm muscle fibers to unilateral denervation

AU - Zhan, W. Z.

AU - Farkas, G. A.

AU - Schroeder, M. A.

AU - Gosselin, L. E.

AU - Sieck, Gary C

PY - 1995

Y1 - 1995

N2 - We hypothesized that adaptations of the rabbit diaphragm (Dia) after unilateral denervation (DNV) result from removal of a neural influence rather than from passive stress. Length changes of midcostal and sternal Dia regions were measured before and after DNV by using sonomicrometry. Midcostal fibers passively lengthened after DNV, whereas sternal fibers shortened. In both regions, these length changes were associated with minimal stress, as estimated from passive force-length relationships. Morphological and contractile adaptions of midcostal and sternal Dia regions were examined after i and 4 wk of DNV. In both Dia regions, type I fibers progressively hypertrophied, whereas type IIb fibers atrophied. After DNV, changes in isometric contraction were similar in both Dia regions. Twitch contraction and half-relaxation times increased, force-frequency relationships shifted leftward, and maximum tetanic force decreased. We conclude that passive length changes and mechanical stress are not the main determinants of the morphological and contractile adaptations of the Dia after unilateral DNV but that these adaptations result from DNV itself.

AB - We hypothesized that adaptations of the rabbit diaphragm (Dia) after unilateral denervation (DNV) result from removal of a neural influence rather than from passive stress. Length changes of midcostal and sternal Dia regions were measured before and after DNV by using sonomicrometry. Midcostal fibers passively lengthened after DNV, whereas sternal fibers shortened. In both regions, these length changes were associated with minimal stress, as estimated from passive force-length relationships. Morphological and contractile adaptions of midcostal and sternal Dia regions were examined after i and 4 wk of DNV. In both Dia regions, type I fibers progressively hypertrophied, whereas type IIb fibers atrophied. After DNV, changes in isometric contraction were similar in both Dia regions. Twitch contraction and half-relaxation times increased, force-frequency relationships shifted leftward, and maximum tetanic force decreased. We conclude that passive length changes and mechanical stress are not the main determinants of the morphological and contractile adaptations of the Dia after unilateral DNV but that these adaptations result from DNV itself.

KW - cross-sectional area

KW - hemidiaphragm

KW - passive stretch

KW - sonomicrometry

UR - http://www.scopus.com/inward/record.url?scp=0029049432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029049432&partnerID=8YFLogxK

M3 - Article

C2 - 8567538

AN - SCOPUS:0029049432

VL - 79

SP - 941

EP - 950

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -