Refractory thrombocytopenia due to anti-PLA1 antibodies following autologous peripheral blood stem cell transplantation: Case report and review of literature

V. Roy, C. M. Verfaillie

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A 43-year-old woman developed life-threatening refractory thrombocytopenia following autologous peripheral blood stem cell transplantation for metastatic breast carcinoma. Anti-PLA1 antibodies were demonstrated in the patient's plasma. Treatment with intravenous immunogiobulin and transfusion of PLA1-negative blood products restored platelet responsiveness. PLA1 alloantibodies should be considered as a possible cause of severe refractory thrombocytopenia in marrow transplant patients. It is important to make this diagnosis as the mainstay of treatment is the avoidance of blood products from PLA1-positive donors (98% of the population).

Original languageEnglish (US)
Pages (from-to)115-117
Number of pages3
JournalBone Marrow Transplantation
Volume17
Issue number1
StatePublished - Jan 1 1996

Keywords

  • Anti-PL antibodies
  • Peripheral blood stem cells
  • Thrombocytopenia

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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