Reflections 1 year into the 21-center national institutes of health-funded wrist study: A primer on conducting a multicenter clinical trial

Kevin C. Chung; H. Myra Kim; Steven C. Haase; Jeffrey Lawton; Kagan Ozer; Jennifer F. Waljee; Kate Nellans; Sunitha Malay; Melissa J. Shauver; Tamara D. Rozental; Paul Appleton; Edward Rodriguez; Lindsay Herder; Katiri Wagner; Philip Blazar; Brandon Earp; W. Emerson Floyd; Katherine S. Pico; Marc J. Richards; David S. Ruch; Suzanne Finley; Loree K. Kalliainen; James W. Fletcher; Cherrie A. Heinrich; Christian M. Ward; Brian W. Hill; Brent Bamberger; Carla Robinson; Brandi Palmer; David Ring; Jesse B. Jupiter; Rajesh Reddy; David Dennison; Sanjeev Kakar; Alexander Shin; Tyson Scrabeck; Harry Hoyen; Kevin Malone; Sandeep Sebastin; Poh Ling Tay; Glenn Gaston; Benjamin Connell; Michael Neumeister; Nada N. Berry; Reuben A. Bueno; Mark McAndrew; Jennifer Koechle; Bertrand Perey; Mauri Zomar; Jennifer Moriatis Wolf; Craig M. Rodner; Mark Cote; Tod Clark; Thomas Lehman; Kathy Carl; David Bozentka; Scott Levin; David Steinberg; Annamarie Horan; Denise Knox; Warren Hammert; Allison W. McIntyre; Jeffrey B. Friedrich; Christopher H. Allan; Douglas P. Hanel; Jerry I. Huang; Jason H. Ko; Nicholas B. Vedder; David Boman; Claudette L. Cooper; Ruby Grewal; Joy MacDermid; Kate Kelly; Kristie Millman; Zhongyu Li; Andrew Koman; Beth Smith; Debra Bullard

doi:10.1016/j.jhsa.2013.02.027

Reflections 1 year into the 21-center national institutes of health-funded wrist study: A primer on conducting a multicenter clinical trial

Kevin C. Chung, H. Myra Kim, Steven C. Haase, Jeffrey Lawton, Kagan Ozer, Jennifer F. Waljee, Kate Nellans, Sunitha Malay, Melissa J. Shauver, Tamara D. Rozental, Paul Appleton, Edward Rodriguez, Lindsay Herder, Katiri Wagner, Philip Blazar, Brandon Earp, W. Emerson Floyd, Katherine S. Pico, Marc J. Richards, David S. RuchSuzanne Finley, Loree K. Kalliainen, James W. Fletcher, Cherrie A. Heinrich, Christian M. Ward, Brian W. Hill, Brent Bamberger, Carla Robinson, Brandi Palmer, David Ring, Jesse B. Jupiter, Rajesh Reddy, David Dennison, Sanjeev Kakar, Alexander Shin, Tyson Scrabeck, Harry Hoyen, Kevin Malone, Sandeep Sebastin, Poh Ling Tay, Glenn Gaston, Benjamin Connell, Michael Neumeister, Nada N. Berry, Reuben A. Bueno, Mark McAndrew, Jennifer Koechle, Bertrand Perey, Mauri Zomar, Jennifer Moriatis Wolf, Craig M. Rodner, Mark Cote, Tod Clark, Thomas Lehman, Kathy Carl, David Bozentka, Scott Levin, David Steinberg, Annamarie Horan, Denise Knox, Warren Hammert, Allison W. McIntyre, Jeffrey B. Friedrich, Christopher H. Allan, Douglas P. Hanel, Jerry I. Huang, Jason H. Ko, Nicholas B. Vedder, David Boman, Claudette L. Cooper, Ruby Grewal, Joy MacDermid, Kate Kelly, Kristie Millman, Zhongyu Li, Andrew Koman, Beth Smith, Debra Bullard

Orthopedic Surgery

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The Wrist and Radius Injury Surgery Trial (WRIST) study group is a collaboration of 21 hand surgery centers in the United States, Canada, and Singapore, to showcase the interest and capability of hand surgeons to conduct a multicenter clinical trial. The WRIST study group was formed in response to the seminal systematic review by Margaliot et al and the Cochrane report that indicated marked deficiency in the quality of evidence in the distal radius fracture literature. Since the initial description of this fracture by Colles in 1814, over 2,000 studies have been published on this subject; yet, high-level studies based on the principles of evidence-based medicine are lacking. As we continue to embrace evidence-based medicine to raise the quality of research, the lessons learned during the organization and conduct of WRIST can serve as a template for others contemplating similar efforts. This article traces the course of WRIST by sharing the triumphs and, more important, the struggles faced in the first year of this study.

Original language	English (US)
Pages (from-to)	1194-1201
Number of pages	8
Journal	Journal of Hand Surgery
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.jhsa.2013.02.027
State	Published - Jun 2013

Keywords

Distal radius fracture
multicenter trials
randomized clinical trials

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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10.1016/j.jhsa.2013.02.027

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Chung, K. C., Kim, H. M., Haase, S. C., Lawton, J., Ozer, K., Waljee, J. F., Nellans, K., Malay, S., Shauver, M. J., Rozental, T. D., Appleton, P., Rodriguez, E., Herder, L., Wagner, K., Blazar, P., Earp, B., Floyd, W. E., Pico, K. S., Richards, M. J., ... Bullard, D. (2013). Reflections 1 year into the 21-center national institutes of health-funded wrist study: A primer on conducting a multicenter clinical trial. Journal of Hand Surgery, 38(6), 1194-1201. https://doi.org/10.1016/j.jhsa.2013.02.027

Chung, KC, Kim, HM, Haase, SC, Lawton, J, Ozer, K, Waljee, JF, Nellans, K, Malay, S, Shauver, MJ, Rozental, TD, Appleton, P, Rodriguez, E, Herder, L, Wagner, K, Blazar, P, Earp, B, Floyd, WE, Pico, KS, Richards, MJ, Ruch, DS, Finley, S, Kalliainen, LK, Fletcher, JW, Heinrich, CA, Ward, CM, Hill, BW, Bamberger, B, Robinson, C, Palmer, B, Ring, D, Jupiter, JB, Reddy, R, Dennison, D, Kakar, S, Shin, A, Scrabeck, T, Hoyen, H, Malone, K, Sebastin, S, Tay, PL, Gaston, G, Connell, B, Neumeister, M, Berry, NN, Bueno, RA, McAndrew, M, Koechle, J, Perey, B, Zomar, M, Wolf, JM, Rodner, CM, Cote, M, Clark, T, Lehman, T, Carl, K, Bozentka, D, Levin, S, Steinberg, D, Horan, A, Knox, D, Hammert, W, McIntyre, AW, Friedrich, JB, Allan, CH, Hanel, DP, Huang, JI, Ko, JH, Vedder, NB, Boman, D, Cooper, CL, Grewal, R, MacDermid, J, Kelly, K, Millman, K, Li, Z, Koman, A, Smith, B & Bullard, D 2013, 'Reflections 1 year into the 21-center national institutes of health-funded wrist study: A primer on conducting a multicenter clinical trial', Journal of Hand Surgery, vol. 38, no. 6, pp. 1194-1201. https://doi.org/10.1016/j.jhsa.2013.02.027

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title = "Reflections 1 year into the 21-center national institutes of health-funded wrist study: A primer on conducting a multicenter clinical trial",

abstract = "The Wrist and Radius Injury Surgery Trial (WRIST) study group is a collaboration of 21 hand surgery centers in the United States, Canada, and Singapore, to showcase the interest and capability of hand surgeons to conduct a multicenter clinical trial. The WRIST study group was formed in response to the seminal systematic review by Margaliot et al and the Cochrane report that indicated marked deficiency in the quality of evidence in the distal radius fracture literature. Since the initial description of this fracture by Colles in 1814, over 2,000 studies have been published on this subject; yet, high-level studies based on the principles of evidence-based medicine are lacking. As we continue to embrace evidence-based medicine to raise the quality of research, the lessons learned during the organization and conduct of WRIST can serve as a template for others contemplating similar efforts. This article traces the course of WRIST by sharing the triumphs and, more important, the struggles faced in the first year of this study.",

keywords = "Distal radius fracture, multicenter trials, randomized clinical trials",

author = "Chung, {Kevin C.} and Kim, {H. Myra} and Haase, {Steven C.} and Jeffrey Lawton and Kagan Ozer and Waljee, {Jennifer F.} and Kate Nellans and Sunitha Malay and Shauver, {Melissa J.} and Rozental, {Tamara D.} and Paul Appleton and Edward Rodriguez and Lindsay Herder and Katiri Wagner and Philip Blazar and Brandon Earp and Floyd, {W. Emerson} and Pico, {Katherine S.} and Richards, {Marc J.} and Ruch, {David S.} and Suzanne Finley and Kalliainen, {Loree K.} and Fletcher, {James W.} and Heinrich, {Cherrie A.} and Ward, {Christian M.} and Hill, {Brian W.} and Brent Bamberger and Carla Robinson and Brandi Palmer and David Ring and Jupiter, {Jesse B.} and Rajesh Reddy and David Dennison and Sanjeev Kakar and Alexander Shin and Tyson Scrabeck and Harry Hoyen and Kevin Malone and Sandeep Sebastin and Tay, {Poh Ling} and Glenn Gaston and Benjamin Connell and Michael Neumeister and Berry, {Nada N.} and Bueno, {Reuben A.} and Mark McAndrew and Jennifer Koechle and Bertrand Perey and Mauri Zomar and Wolf, {Jennifer Moriatis} and Rodner, {Craig M.} and Mark Cote and Tod Clark and Thomas Lehman and Kathy Carl and David Bozentka and Scott Levin and David Steinberg and Annamarie Horan and Denise Knox and Warren Hammert and McIntyre, {Allison W.} and Friedrich, {Jeffrey B.} and Allan, {Christopher H.} and Hanel, {Douglas P.} and Huang, {Jerry I.} and Ko, {Jason H.} and Vedder, {Nicholas B.} and David Boman and Cooper, {Claudette L.} and Ruby Grewal and Joy MacDermid and Kate Kelly and Kristie Millman and Zhongyu Li and Andrew Koman and Beth Smith and Debra Bullard",

year = "2013",

month = jun,

doi = "10.1016/j.jhsa.2013.02.027",

language = "English (US)",

volume = "38",

pages = "1194--1201",

journal = "Journal of Hand Surgery",

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AU - Haase, Steven C.

AU - Lawton, Jeffrey

AU - Ozer, Kagan

AU - Waljee, Jennifer F.

AU - Nellans, Kate

AU - Malay, Sunitha

AU - Shauver, Melissa J.

AU - Rozental, Tamara D.

AU - Appleton, Paul

AU - Rodriguez, Edward

AU - Herder, Lindsay

AU - Wagner, Katiri

AU - Blazar, Philip

AU - Earp, Brandon

AU - Floyd, W. Emerson

AU - Pico, Katherine S.

AU - Richards, Marc J.

AU - Ruch, David S.

AU - Finley, Suzanne

AU - Kalliainen, Loree K.

AU - Fletcher, James W.

AU - Heinrich, Cherrie A.

AU - Ward, Christian M.

AU - Hill, Brian W.

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AU - Palmer, Brandi

AU - Ring, David

AU - Jupiter, Jesse B.

AU - Reddy, Rajesh

AU - Dennison, David

AU - Kakar, Sanjeev

AU - Shin, Alexander

AU - Scrabeck, Tyson

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AU - Malone, Kevin

AU - Sebastin, Sandeep

AU - Tay, Poh Ling

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AU - Connell, Benjamin

AU - Neumeister, Michael

AU - Berry, Nada N.

AU - Bueno, Reuben A.

AU - McAndrew, Mark

AU - Koechle, Jennifer

AU - Perey, Bertrand

AU - Zomar, Mauri

AU - Wolf, Jennifer Moriatis

AU - Rodner, Craig M.

AU - Cote, Mark

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AU - Knox, Denise

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AU - McIntyre, Allison W.

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AU - Huang, Jerry I.

AU - Ko, Jason H.

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AU - Cooper, Claudette L.

AU - Grewal, Ruby

AU - MacDermid, Joy

AU - Kelly, Kate

AU - Millman, Kristie

AU - Li, Zhongyu

AU - Koman, Andrew

AU - Smith, Beth

AU - Bullard, Debra

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Reflections 1 year into the 21-center national institutes of health-funded wrist study: A primer on conducting a multicenter clinical trial

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ASJC Scopus subject areas

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