Referenceless stratification of parenchymal lung abnormalities

Sushravya Raghunath; Srinivasan Rajagopalan; Ronald A. Karwoski; Brian J. Bartholmai; Richard A. Robb

doi:10.1007/978-3-642-23626-6_28

Referenceless stratification of parenchymal lung abnormalities

Sushravya Raghunath, Srinivasan Rajagopalan, Ronald A. Karwoski, Brian J. Bartholmai, Richard A. Robb

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

This paper introduces computational tools that could enable personalized, predictive, preemptive, and participatory (P4) Pulmonary medicine. We demonstrate approaches to (a) stratify lungs from different subjects based on the spatial distribution of parenchymal abnormality and (b) visualize the stratification through glyphs that convey both the grouping efficacy and an iconic overview of an individual's lung wellness. Affinity propagation based on regional parenchymal abnormalities is used in the referenceless stratification. Abnormalities are computed using supervised classification based on Earth Mover's distance. Twenty natural clusters were detected from 372 CT lung scans. The computed clusters correlated with clinical consensus of 9 disease types. The quality of inter- and intra-cluster stratification as assessed by ANOSIM R was 0.887 ± 0.18 (pval < 0.0005). The proposed tools could serve as biomarkers to objectively diagnose pathology, track progression and assess pharmacologic response within and across patients.

Original language	English (US)
Title of host publication	Medical Image Computing and Computer-Assisted Intervention, MICCAI 2011 - 14th International Conference, Proceedings
Pages	223-230
Number of pages	8
Edition	PART 3
DOIs	https://doi.org/10.1007/978-3-642-23626-6_28
State	Published - Oct 11 2011
Event	14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011 - Toronto, ON, Canada Duration: Sep 18 2011 → Sep 22 2011

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Number	PART 3
Volume	6893 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011
Country	Canada
City	Toronto, ON
Period	9/18/11 → 9/22/11

Keywords

Referenceless stratification
affinity propagation
glyphs
idiopathic pulmonary fibrosis

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

Access to Document

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Cite this

Raghunath, S., Rajagopalan, S., Karwoski, R. A., Bartholmai, B. J., & Robb, R. A. (2011). Referenceless stratification of parenchymal lung abnormalities. In Medical Image Computing and Computer-Assisted Intervention, MICCAI 2011 - 14th International Conference, Proceedings (PART 3 ed., pp. 223-230). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6893 LNCS, No. PART 3). https://doi.org/10.1007/978-3-642-23626-6_28

Referenceless stratification of parenchymal lung abnormalities. / Raghunath, Sushravya; Rajagopalan, Srinivasan; Karwoski, Ronald A.; Bartholmai, Brian J.; Robb, Richard A.

Medical Image Computing and Computer-Assisted Intervention, MICCAI 2011 - 14th International Conference, Proceedings. PART 3. ed. 2011. p. 223-230 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6893 LNCS, No. PART 3).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Raghunath, S, Rajagopalan, S, Karwoski, RA, Bartholmai, BJ & Robb, RA 2011, Referenceless stratification of parenchymal lung abnormalities. in Medical Image Computing and Computer-Assisted Intervention, MICCAI 2011 - 14th International Conference, Proceedings. PART 3 edn, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), no. PART 3, vol. 6893 LNCS, pp. 223-230, 14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011, Toronto, ON, Canada, 9/18/11. https://doi.org/10.1007/978-3-642-23626-6_28

Raghunath S, Rajagopalan S, Karwoski RA, Bartholmai BJ, Robb RA. Referenceless stratification of parenchymal lung abnormalities. In Medical Image Computing and Computer-Assisted Intervention, MICCAI 2011 - 14th International Conference, Proceedings. PART 3 ed. 2011. p. 223-230. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 3). https://doi.org/10.1007/978-3-642-23626-6_28

Raghunath, Sushravya ; Rajagopalan, Srinivasan ; Karwoski, Ronald A. ; Bartholmai, Brian J. ; Robb, Richard A. / Referenceless stratification of parenchymal lung abnormalities. Medical Image Computing and Computer-Assisted Intervention, MICCAI 2011 - 14th International Conference, Proceedings. PART 3. ed. 2011. pp. 223-230 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); PART 3).

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