TY - JOUR
T1 - Reference ranges for 2-dimensional sonographic lung measurements in healthy fetuses
T2 - A longitudinal study
AU - Britto, Ingrid Schwach Werneck
AU - Araujo, Edward
AU - Sangi-Haghpeykar, Haleh
AU - Bussamra, Luiz Cláudio Silva
AU - Deter, Russell L.
AU - Belfort, Michael A.
AU - Lee, Wesley
AU - Ruano, Rodrigo
N1 - Publisher Copyright:
© 2014 by the American Institute of Ultrasound in Medicine.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Objectives: The purpose of this study was to establish reference ranges for 2-dimensional sonographic measurements of fetal lungs from longitudinal data.Methods: A total of 214 fetal lung measurements were longitudinally evaluated in 62 healthy fetuses between 20 and 36 weeks' menstrual age. Both right and left lung areas were measured in the heart 4-chamber view using lung area tracing and axis diameter methods. Multilevel modeling was used to evaluate the expected values and variability with respect to menstrual age and to generate reference ranges for the lung area, lungto-head ratio, quantitative lung index, and observed-to-expected lung-to-head ratio for both lungs.Results: The expected values varied with menstrual age for all parameters. Variance was menstrual age dependent for all parameters except the longest diameter area measurements and their lung-to-head ratios.Conclusions: Models are presented for expected 2-dimensional sonographic lung size parameters and their variance as a function of menstrual age. These data have been used to generate age-specific reference ranges for both measurements and indices.
AB - Objectives: The purpose of this study was to establish reference ranges for 2-dimensional sonographic measurements of fetal lungs from longitudinal data.Methods: A total of 214 fetal lung measurements were longitudinally evaluated in 62 healthy fetuses between 20 and 36 weeks' menstrual age. Both right and left lung areas were measured in the heart 4-chamber view using lung area tracing and axis diameter methods. Multilevel modeling was used to evaluate the expected values and variability with respect to menstrual age and to generate reference ranges for the lung area, lungto-head ratio, quantitative lung index, and observed-to-expected lung-to-head ratio for both lungs.Results: The expected values varied with menstrual age for all parameters. Variance was menstrual age dependent for all parameters except the longest diameter area measurements and their lung-to-head ratios.Conclusions: Models are presented for expected 2-dimensional sonographic lung size parameters and their variance as a function of menstrual age. These data have been used to generate age-specific reference ranges for both measurements and indices.
KW - Congenital diaphragmatic hernia
KW - Fetal lung
KW - Fetal lung area
KW - Lung-to-head ratio
KW - Obstetric ultrasound
KW - Prenatal diagnosis
KW - Pulmonary hypoplasia
KW - Sonography
UR - http://www.scopus.com/inward/record.url?scp=84908698850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908698850&partnerID=8YFLogxK
U2 - 10.7863/ultra.33.11.1917
DO - 10.7863/ultra.33.11.1917
M3 - Article
C2 - 25336478
AN - SCOPUS:84908698850
SN - 0278-4297
VL - 33
SP - 1917
EP - 1923
JO - Journal of Ultrasound in Medicine
JF - Journal of Ultrasound in Medicine
IS - 11
ER -