Reference range for fetal interventricular septum area by means of four-dimensional ultrasonography using spatiotemporal image correlation

Luciano Marcondes Machado Nardozza, Liliam Cristine Rolo, Edward Araujo Júnior, Alan Roberto Hatanaka, Luciane Alves Rocha, Christiane Simioni, Rodrigo Ruano, Antonio Fernandes Moron

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Objective: To determine reference range for fetal interventricular septum area by means of 3-dimensional ultrasonography (3DUS) using the spatiotemporal image correlation (STIC) method. Methods: A prospective, cross-sectional study was conducted on 328 normal pregnant women between the 18th and 33rd gestational weeks. To obtain the interventricular septum area, a virtual plane was used, with the green line (region of interest) adjacent to the external margin of the septum, which was manually delimited. To evaluate the correlation of the septum area with the gestational age, different regression modes were evaluated. The intraclass correlation coefficient was used to evaluate the interobserver reproducibility. Results: The interventricular septum area showed correlation with the gestational age (r = 0.81). The mean increased from 0.47 ± 0.10 cm2 in the 18th week to 2.42 ± 1.13 cm2 in the 33rd week of gestation. The mathematical equation that best represented this correlation was provided by linear regression: interventricular septum area = 0.0511 × gestational age (R2 = 0.095). The interobserver reproducibility was good, with bias of 0.01 cm2, precision of 0.07 cm2 and absolute limits of agreement of -0.14 and +0.15 cm2. Conclusions: Reference range for fetal interventricular septum area were determined by means of 3DUS using STIC in the rendering mode and were shown to be reproducible.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalFetal Diagnosis and Therapy
Volume33
Issue number2
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

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Keywords

  • Fetal interventricular septum area
  • Spatiotemporal image correlation
  • Three-dimensional ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology

Cite this

Nardozza, L. M. M., Rolo, L. C., Araujo Júnior, E., Hatanaka, A. R., Rocha, L. A., Simioni, C., Ruano, R., & Moron, A. F. (2013). Reference range for fetal interventricular septum area by means of four-dimensional ultrasonography using spatiotemporal image correlation. Fetal Diagnosis and Therapy, 33(2), 110-115. https://doi.org/10.1159/000345650