Reduction of atherothrombotic burden before stent deployment in non-ST elevation acute coronary syndromes

Reduction of myocardial necrosis achieved with nose-dive manual thrombus aspiration (REMNANT) trial. A volumetric intravascular ultrasound study

Marco Zimarino, Francesca Angeramo, Abhiram Prasad, Benedetta Ruggieri, Sara Malatesta, Francesco Prati, Fiamma Buttitta, Raffaele De Caterina

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To test whether thrombus aspiration (TA) reduces the atherosclerotic burden in culprit lesions and "facilitate" percutaneous coronary intervention with stent (S-PCI) among patients with non-ST elevation acute coronary syndromes (NSTE-ACS). Background: Evidence on the effects of TA adjunctive to S-PCI in NSTE-ACS is limited and controversial. Methods: TA was defined "aggressive" when using 7F devices or a catheter/artery ratio >0.6, "conservative" with 6F, and a catheter/artery ratio ≤0.6. Angiography and intravascular ultrasound (IVUS) were performed at baseline, after TA and after stent deployment. Results: TA was accomplished in 61/76 patients (80%) with NSTE-ACS. The aspirated material was red thrombus in 23% and plaque fragments in 49% of cases. Compared with baseline, TA was associated with an 82% increase in minimal lumen diameter and a 15% reduction in diameter stenosis (P

Original languageEnglish (US)
JournalCatheterization and Cardiovascular Interventions
DOIs
StateAccepted/In press - 2015
Externally publishedYes

Fingerprint

Acute Coronary Syndrome
Nose
Stents
Thrombosis
Necrosis
Catheters
Arteries
Percutaneous Coronary Intervention
Angiography
Pathologic Constriction
Equipment and Supplies

Keywords

  • IVUS
  • Non-ST elevation acute coronary syndromes
  • Thrombus aspiration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Reduction of atherothrombotic burden before stent deployment in non-ST elevation acute coronary syndromes : Reduction of myocardial necrosis achieved with nose-dive manual thrombus aspiration (REMNANT) trial. A volumetric intravascular ultrasound study. / Zimarino, Marco; Angeramo, Francesca; Prasad, Abhiram; Ruggieri, Benedetta; Malatesta, Sara; Prati, Francesco; Buttitta, Fiamma; De Caterina, Raffaele.

In: Catheterization and Cardiovascular Interventions, 2015.

Research output: Contribution to journalArticle

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abstract = "Objectives: To test whether thrombus aspiration (TA) reduces the atherosclerotic burden in culprit lesions and {"}facilitate{"} percutaneous coronary intervention with stent (S-PCI) among patients with non-ST elevation acute coronary syndromes (NSTE-ACS). Background: Evidence on the effects of TA adjunctive to S-PCI in NSTE-ACS is limited and controversial. Methods: TA was defined {"}aggressive{"} when using 7F devices or a catheter/artery ratio >0.6, {"}conservative{"} with 6F, and a catheter/artery ratio ≤0.6. Angiography and intravascular ultrasound (IVUS) were performed at baseline, after TA and after stent deployment. Results: TA was accomplished in 61/76 patients (80{\%}) with NSTE-ACS. The aspirated material was red thrombus in 23{\%} and plaque fragments in 49{\%} of cases. Compared with baseline, TA was associated with an 82{\%} increase in minimal lumen diameter and a 15{\%} reduction in diameter stenosis (P",
keywords = "IVUS, Non-ST elevation acute coronary syndromes, Thrombus aspiration",
author = "Marco Zimarino and Francesca Angeramo and Abhiram Prasad and Benedetta Ruggieri and Sara Malatesta and Francesco Prati and Fiamma Buttitta and {De Caterina}, Raffaele",
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T1 - Reduction of atherothrombotic burden before stent deployment in non-ST elevation acute coronary syndromes

T2 - Reduction of myocardial necrosis achieved with nose-dive manual thrombus aspiration (REMNANT) trial. A volumetric intravascular ultrasound study

AU - Zimarino, Marco

AU - Angeramo, Francesca

AU - Prasad, Abhiram

AU - Ruggieri, Benedetta

AU - Malatesta, Sara

AU - Prati, Francesco

AU - Buttitta, Fiamma

AU - De Caterina, Raffaele

PY - 2015

Y1 - 2015

N2 - Objectives: To test whether thrombus aspiration (TA) reduces the atherosclerotic burden in culprit lesions and "facilitate" percutaneous coronary intervention with stent (S-PCI) among patients with non-ST elevation acute coronary syndromes (NSTE-ACS). Background: Evidence on the effects of TA adjunctive to S-PCI in NSTE-ACS is limited and controversial. Methods: TA was defined "aggressive" when using 7F devices or a catheter/artery ratio >0.6, "conservative" with 6F, and a catheter/artery ratio ≤0.6. Angiography and intravascular ultrasound (IVUS) were performed at baseline, after TA and after stent deployment. Results: TA was accomplished in 61/76 patients (80%) with NSTE-ACS. The aspirated material was red thrombus in 23% and plaque fragments in 49% of cases. Compared with baseline, TA was associated with an 82% increase in minimal lumen diameter and a 15% reduction in diameter stenosis (P

AB - Objectives: To test whether thrombus aspiration (TA) reduces the atherosclerotic burden in culprit lesions and "facilitate" percutaneous coronary intervention with stent (S-PCI) among patients with non-ST elevation acute coronary syndromes (NSTE-ACS). Background: Evidence on the effects of TA adjunctive to S-PCI in NSTE-ACS is limited and controversial. Methods: TA was defined "aggressive" when using 7F devices or a catheter/artery ratio >0.6, "conservative" with 6F, and a catheter/artery ratio ≤0.6. Angiography and intravascular ultrasound (IVUS) were performed at baseline, after TA and after stent deployment. Results: TA was accomplished in 61/76 patients (80%) with NSTE-ACS. The aspirated material was red thrombus in 23% and plaque fragments in 49% of cases. Compared with baseline, TA was associated with an 82% increase in minimal lumen diameter and a 15% reduction in diameter stenosis (P

KW - IVUS

KW - Non-ST elevation acute coronary syndromes

KW - Thrombus aspiration

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