Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Daniel J. Apicco, Peter E.A. Ash, Brandon Maziuk, Chelsey Leblang, Maria Medalla, Ali Al Abdullatif, Antonio Ferragud, Emily Botelho, Heather I. Ballance, Uma Dhawan, Samantha Boudeau, Anna Lourdes Cruz, Daniel Kashy, Aria Wong, Lisa R. Goldberg, Neema Yazdani, Cheng Zhang, Choong Y. Ung, Yorghos Tripodis, Nicholas M. KanaanTsuneya Ikezu, Pietro Cottone, John Leszyk, Hu Li, Jennifer Luebke, Camron D. Bryant, Benjamin Wolozin

Research output: Contribution to journalArticle

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Abstract

Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo protects against neurodegeneration and prolongs survival in transgenic P301S Tau mice. Biochemical fractionation shows co-enrichment and co-localization of tau oligomers and RBPs in transgenic P301S Tau mice. Reducing TIA1 decreased the number and size of granules co-localizing with stress granule markers. Decreasing TIA1 also inhibited the accumulation of tau oligomers at the expense of increasing neurofibrillary tangles. Despite the increase in neurofibrillary tangles, TIA1 reduction increased neuronal survival and rescued behavioral deficits and lifespan. These data provide in vivo evidence that TIA1 plays a key role in mediating toxicity and further suggest that RBPs direct the pathway of tau aggregation and the resulting neurodegeneration. We propose a model in which dysfunction of the translational stress response leads to tau-mediated pathology.

Original languageEnglish (US)
Pages (from-to)72-82
Number of pages11
JournalNature Neuroscience
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2018

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RNA-Binding Proteins
T-Lymphocytes
Antigens
Neurofibrillary Tangles
Pathology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Apicco, D. J., Ash, P. E. A., Maziuk, B., Leblang, C., Medalla, M., Al Abdullatif, A., ... Wolozin, B. (2018). Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nature Neuroscience, 21(1), 72-82. https://doi.org/10.1038/s41593-017-0022-z

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. / Apicco, Daniel J.; Ash, Peter E.A.; Maziuk, Brandon; Leblang, Chelsey; Medalla, Maria; Al Abdullatif, Ali; Ferragud, Antonio; Botelho, Emily; Ballance, Heather I.; Dhawan, Uma; Boudeau, Samantha; Cruz, Anna Lourdes; Kashy, Daniel; Wong, Aria; Goldberg, Lisa R.; Yazdani, Neema; Zhang, Cheng; Ung, Choong Y.; Tripodis, Yorghos; Kanaan, Nicholas M.; Ikezu, Tsuneya; Cottone, Pietro; Leszyk, John; Li, Hu; Luebke, Jennifer; Bryant, Camron D.; Wolozin, Benjamin.

In: Nature Neuroscience, Vol. 21, No. 1, 01.01.2018, p. 72-82.

Research output: Contribution to journalArticle

Apicco, DJ, Ash, PEA, Maziuk, B, Leblang, C, Medalla, M, Al Abdullatif, A, Ferragud, A, Botelho, E, Ballance, HI, Dhawan, U, Boudeau, S, Cruz, AL, Kashy, D, Wong, A, Goldberg, LR, Yazdani, N, Zhang, C, Ung, CY, Tripodis, Y, Kanaan, NM, Ikezu, T, Cottone, P, Leszyk, J, Li, H, Luebke, J, Bryant, CD & Wolozin, B 2018, 'Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo', Nature Neuroscience, vol. 21, no. 1, pp. 72-82. https://doi.org/10.1038/s41593-017-0022-z
Apicco DJ, Ash PEA, Maziuk B, Leblang C, Medalla M, Al Abdullatif A et al. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nature Neuroscience. 2018 Jan 1;21(1):72-82. https://doi.org/10.1038/s41593-017-0022-z
Apicco, Daniel J. ; Ash, Peter E.A. ; Maziuk, Brandon ; Leblang, Chelsey ; Medalla, Maria ; Al Abdullatif, Ali ; Ferragud, Antonio ; Botelho, Emily ; Ballance, Heather I. ; Dhawan, Uma ; Boudeau, Samantha ; Cruz, Anna Lourdes ; Kashy, Daniel ; Wong, Aria ; Goldberg, Lisa R. ; Yazdani, Neema ; Zhang, Cheng ; Ung, Choong Y. ; Tripodis, Yorghos ; Kanaan, Nicholas M. ; Ikezu, Tsuneya ; Cottone, Pietro ; Leszyk, John ; Li, Hu ; Luebke, Jennifer ; Bryant, Camron D. ; Wolozin, Benjamin. / Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. In: Nature Neuroscience. 2018 ; Vol. 21, No. 1. pp. 72-82.
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