Reducing Senescent Cell Burden in Aging and Disease

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Cellular senescence is a primary aging process and tumor suppressive mechanism characterized by irreversible growth arrest, apoptosis resistance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, and alterations in DNA and chromatin. In preclinical aging models, accumulation of senescent cells is associated with multiple chronic diseases and disorders, geriatric syndromes, multimorbidity, and accelerated aging phenotypes. In animals, genetic and pharmacologic reduction of senescent cell burden results in the prevention, delay, and/or alleviation of a variety of aging-related diseases and sequelae. Early clinical trials have thus far focused on safety and target engagement of senolytic agents that clear senescent cells. We hypothesize that these pharmacologic interventions may have transformative effects on geriatric medicine.

Original languageEnglish (US)
Pages (from-to)630-638
Number of pages9
JournalTrends in Molecular Medicine
Volume26
Issue number7
DOIs
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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