Reducing friction by chemically modifying the surface of extrasynovial tendon grafts

Yu Long Sun; Chao Yang; Peter C. Amadio; Chunfeng Zhao; Mark E. Zobitz; Kai Nan An

doi:10.1016/j.orthres.2004.02.005

Reducing friction by chemically modifying the surface of extrasynovial tendon grafts

Yu Long Sun, Chao Yang, Peter C. Amadio, Chunfeng Zhao, Mark E. Zobitz, Kai Nan An

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

In this study we evaluated methods to reduce the friction of an extrasynovial tendon under a pulley in vitro. The surface of canine peroneus longus (PL) tendons was modified with gelatin and/or hyaluronic acid (HA) under different conditions. The gliding resistance between treated or control tendons and the canine digital flexor pulley was measured during 500 cycles of simulated flexion/extension. After 500 cycles, the gliding resistance of normal PL tendon increased 10-fold (p<0.05), while the gliding resistance of tendons coated with carbodiimide derivatized gelatin (cd-gelatin) or carbodiimide derivatized gelatin/HA (cd-gelatin-HA) did not increase significantly. The PL tendon treated with cd-gelatin-HA had a similar friction response during the repetitive motion as the intrasynovial flexor digitorum profundus (FDP) tendon. Scanning electron microscopy after 500 cycles of motion showed that the tendon surface in the group treated with cd-gelatin-HA appeared smoother than tendons in the other groups.

Original language	English (US)
Pages (from-to)	984-989
Number of pages	6
Journal	Journal of Orthopaedic Research
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/j.orthres.2004.02.005
State	Published - Sep 2004

Keywords

Adhesion
Chemical modification
Cross-linking
Extrasynovial tendon
Friction

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.orthres.2004.02.005

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title = "Reducing friction by chemically modifying the surface of extrasynovial tendon grafts",

abstract = "In this study we evaluated methods to reduce the friction of an extrasynovial tendon under a pulley in vitro. The surface of canine peroneus longus (PL) tendons was modified with gelatin and/or hyaluronic acid (HA) under different conditions. The gliding resistance between treated or control tendons and the canine digital flexor pulley was measured during 500 cycles of simulated flexion/extension. After 500 cycles, the gliding resistance of normal PL tendon increased 10-fold (p<0.05), while the gliding resistance of tendons coated with carbodiimide derivatized gelatin (cd-gelatin) or carbodiimide derivatized gelatin/HA (cd-gelatin-HA) did not increase significantly. The PL tendon treated with cd-gelatin-HA had a similar friction response during the repetitive motion as the intrasynovial flexor digitorum profundus (FDP) tendon. Scanning electron microscopy after 500 cycles of motion showed that the tendon surface in the group treated with cd-gelatin-HA appeared smoother than tendons in the other groups.",

keywords = "Adhesion, Chemical modification, Cross-linking, Extrasynovial tendon, Friction",

author = "Sun, {Yu Long} and Chao Yang and Amadio, {Peter C.} and Chunfeng Zhao and Zobitz, {Mark E.} and An, {Kai Nan}",

note = "Funding Information: This study was supported by grants from NIH-NIAMS (AR44391) and Mayo Foundation.",

year = "2004",

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doi = "10.1016/j.orthres.2004.02.005",

language = "English (US)",

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AU - Sun, Yu Long

AU - Yang, Chao

AU - Amadio, Peter C.

AU - Zhao, Chunfeng

AU - Zobitz, Mark E.

AU - An, Kai Nan

N1 - Funding Information: This study was supported by grants from NIH-NIAMS (AR44391) and Mayo Foundation.

PY - 2004/9

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N2 - In this study we evaluated methods to reduce the friction of an extrasynovial tendon under a pulley in vitro. The surface of canine peroneus longus (PL) tendons was modified with gelatin and/or hyaluronic acid (HA) under different conditions. The gliding resistance between treated or control tendons and the canine digital flexor pulley was measured during 500 cycles of simulated flexion/extension. After 500 cycles, the gliding resistance of normal PL tendon increased 10-fold (p<0.05), while the gliding resistance of tendons coated with carbodiimide derivatized gelatin (cd-gelatin) or carbodiimide derivatized gelatin/HA (cd-gelatin-HA) did not increase significantly. The PL tendon treated with cd-gelatin-HA had a similar friction response during the repetitive motion as the intrasynovial flexor digitorum profundus (FDP) tendon. Scanning electron microscopy after 500 cycles of motion showed that the tendon surface in the group treated with cd-gelatin-HA appeared smoother than tendons in the other groups.

AB - In this study we evaluated methods to reduce the friction of an extrasynovial tendon under a pulley in vitro. The surface of canine peroneus longus (PL) tendons was modified with gelatin and/or hyaluronic acid (HA) under different conditions. The gliding resistance between treated or control tendons and the canine digital flexor pulley was measured during 500 cycles of simulated flexion/extension. After 500 cycles, the gliding resistance of normal PL tendon increased 10-fold (p<0.05), while the gliding resistance of tendons coated with carbodiimide derivatized gelatin (cd-gelatin) or carbodiimide derivatized gelatin/HA (cd-gelatin-HA) did not increase significantly. The PL tendon treated with cd-gelatin-HA had a similar friction response during the repetitive motion as the intrasynovial flexor digitorum profundus (FDP) tendon. Scanning electron microscopy after 500 cycles of motion showed that the tendon surface in the group treated with cd-gelatin-HA appeared smoother than tendons in the other groups.

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KW - Chemical modification

KW - Cross-linking

KW - Extrasynovial tendon

KW - Friction

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Reducing friction by chemically modifying the surface of extrasynovial tendon grafts

Abstract

Keywords

ASJC Scopus subject areas

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