Reduced visual evoked responses in multiple sclerosis patients with optic neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials

P. J. Gareau, J. S. Gati, R. S. Menon, D. Lee, G. Rice, Joseph Ross Mitchell, P. Mandelfino, S. J. Karlik

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by differences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in the primary visual cortex, measured by fMRI techniques, is dramatically reduced in response to stimulation of the affected eye. The latency of the major positive component of the visual evoked potential (VEP) recorded upon stimulation of the affected eye is significantly increased in these patients, as compared to the unaffected eye and normal volunteers. We have found a correlation between the neural response measured using fMRl and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topogrophic information relating to functional deficits in MS.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalMultiple Sclerosis
Volume5
Issue number3
StatePublished - Jun 1999
Externally publishedYes

Fingerprint

Optic Neuritis
Visual Evoked Potentials
Multiple Sclerosis
Magnetic Resonance Imaging
Visual Cortex
Healthy Volunteers

Keywords

  • Functional magnetic resonance imaging
  • Multiple sclerosis
  • Neurophysiological tests
  • Optic neuritis
  • Visual evoked potentials
  • Visual stimulation

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Gareau, P. J., Gati, J. S., Menon, R. S., Lee, D., Rice, G., Mitchell, J. R., ... Karlik, S. J. (1999). Reduced visual evoked responses in multiple sclerosis patients with optic neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials. Multiple Sclerosis, 5(3), 161-164.

Reduced visual evoked responses in multiple sclerosis patients with optic neuritis : Comparison of functional magnetic resonance imaging and visual evoked potentials. / Gareau, P. J.; Gati, J. S.; Menon, R. S.; Lee, D.; Rice, G.; Mitchell, Joseph Ross; Mandelfino, P.; Karlik, S. J.

In: Multiple Sclerosis, Vol. 5, No. 3, 06.1999, p. 161-164.

Research output: Contribution to journalArticle

Gareau, PJ, Gati, JS, Menon, RS, Lee, D, Rice, G, Mitchell, JR, Mandelfino, P & Karlik, SJ 1999, 'Reduced visual evoked responses in multiple sclerosis patients with optic neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials', Multiple Sclerosis, vol. 5, no. 3, pp. 161-164.
Gareau, P. J. ; Gati, J. S. ; Menon, R. S. ; Lee, D. ; Rice, G. ; Mitchell, Joseph Ross ; Mandelfino, P. ; Karlik, S. J. / Reduced visual evoked responses in multiple sclerosis patients with optic neuritis : Comparison of functional magnetic resonance imaging and visual evoked potentials. In: Multiple Sclerosis. 1999 ; Vol. 5, No. 3. pp. 161-164.
@article{9f67e9dc298a4eadb87590ad93cc5ae7,
title = "Reduced visual evoked responses in multiple sclerosis patients with optic neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials",
abstract = "The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by differences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in the primary visual cortex, measured by fMRI techniques, is dramatically reduced in response to stimulation of the affected eye. The latency of the major positive component of the visual evoked potential (VEP) recorded upon stimulation of the affected eye is significantly increased in these patients, as compared to the unaffected eye and normal volunteers. We have found a correlation between the neural response measured using fMRl and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topogrophic information relating to functional deficits in MS.",
keywords = "Functional magnetic resonance imaging, Multiple sclerosis, Neurophysiological tests, Optic neuritis, Visual evoked potentials, Visual stimulation",
author = "Gareau, {P. J.} and Gati, {J. S.} and Menon, {R. S.} and D. Lee and G. Rice and Mitchell, {Joseph Ross} and P. Mandelfino and Karlik, {S. J.}",
year = "1999",
month = "6",
language = "English (US)",
volume = "5",
pages = "161--164",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Reduced visual evoked responses in multiple sclerosis patients with optic neuritis

T2 - Comparison of functional magnetic resonance imaging and visual evoked potentials

AU - Gareau, P. J.

AU - Gati, J. S.

AU - Menon, R. S.

AU - Lee, D.

AU - Rice, G.

AU - Mitchell, Joseph Ross

AU - Mandelfino, P.

AU - Karlik, S. J.

PY - 1999/6

Y1 - 1999/6

N2 - The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by differences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in the primary visual cortex, measured by fMRI techniques, is dramatically reduced in response to stimulation of the affected eye. The latency of the major positive component of the visual evoked potential (VEP) recorded upon stimulation of the affected eye is significantly increased in these patients, as compared to the unaffected eye and normal volunteers. We have found a correlation between the neural response measured using fMRl and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topogrophic information relating to functional deficits in MS.

AB - The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by differences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in the primary visual cortex, measured by fMRI techniques, is dramatically reduced in response to stimulation of the affected eye. The latency of the major positive component of the visual evoked potential (VEP) recorded upon stimulation of the affected eye is significantly increased in these patients, as compared to the unaffected eye and normal volunteers. We have found a correlation between the neural response measured using fMRl and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topogrophic information relating to functional deficits in MS.

KW - Functional magnetic resonance imaging

KW - Multiple sclerosis

KW - Neurophysiological tests

KW - Optic neuritis

KW - Visual evoked potentials

KW - Visual stimulation

UR - http://www.scopus.com/inward/record.url?scp=0033001940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033001940&partnerID=8YFLogxK

M3 - Article

C2 - 10408715

AN - SCOPUS:0033001940

VL - 5

SP - 161

EP - 164

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 3

ER -