Reduced visual evoked responses in multiple sclerosis patients with optic neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials

P. J. Gareau, J. S. Gati, R. S. Menon, D. Lee, G. Rice, J. R. Mitchell, P. Mandelfino, S. J. Karlik

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by differences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in the primary visual cortex, measured by fMRI techniques, is dramatically reduced in response to stimulation of the affected eye. The latency of the major positive component of the visual evoked potential (VEP) recorded upon stimulation of the affected eye is significantly increased in these patients, as compared to the unaffected eye and normal volunteers. We have found a correlation between the neural response measured using fMRl and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topogrophic information relating to functional deficits in MS.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalMultiple Sclerosis
Volume5
Issue number3
DOIs
StatePublished - Jun 1999

Keywords

  • Functional magnetic resonance imaging
  • Multiple sclerosis
  • Neurophysiological tests
  • Optic neuritis
  • Visual evoked potentials
  • Visual stimulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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