Reduced somatostatin-like immunoreactivity in cerebral cortex in nonfamilial dysphasic dementia

M. F. Mehler, D. S. Horoupian, P. Davies, Dennis W Dickson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A nonfamilial syndrome is described in two middle-aged men who presented with progressive aphasia without incipient signs of cognitive impairment. In each case, 2 years elapsed before progressive functional decline or behavioral disabilities supervened. Radiologic studies documented asymmetric left cerebral atrophy that was progressive. The structure of the language disintegration was distinctive and not like that in Alzheimer's disease. Pathologic studies performed at postmortem examination of one patient documented asymmetric cerebral atrophy with nonspecific histopathologic changes. Biochemical studies revealed normal tissue levels of choline acetyltransferase activity, but reduced somatostatin-like immunoreactivity. Since cerebral somatostatin is largely present in intrinsic cortical neurons, while cholinergic innervation is largely derived from the basal forebrain, these findings suggest that nonfamilial dysphasic dementia may be an example of a distinct class of dementia due to intrinsic cortical degeneration, with sparing of the basal forebrain.

Original languageEnglish (US)
Pages (from-to)1448-1453
Number of pages6
JournalNeurology
Volume37
Issue number9
StatePublished - 1987
Externally publishedYes

Fingerprint

Cerebral Cortex
Atrophy
Dementia
Cholinergic Neurons
Choline O-Acetyltransferase
Aphasia
Somatostatin
Autopsy
Alzheimer Disease
Language
somatostatin-like peptides
Basal Forebrain
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Reduced somatostatin-like immunoreactivity in cerebral cortex in nonfamilial dysphasic dementia. / Mehler, M. F.; Horoupian, D. S.; Davies, P.; Dickson, Dennis W.

In: Neurology, Vol. 37, No. 9, 1987, p. 1448-1453.

Research output: Contribution to journalArticle

Mehler, MF, Horoupian, DS, Davies, P & Dickson, DW 1987, 'Reduced somatostatin-like immunoreactivity in cerebral cortex in nonfamilial dysphasic dementia', Neurology, vol. 37, no. 9, pp. 1448-1453.
Mehler, M. F. ; Horoupian, D. S. ; Davies, P. ; Dickson, Dennis W. / Reduced somatostatin-like immunoreactivity in cerebral cortex in nonfamilial dysphasic dementia. In: Neurology. 1987 ; Vol. 37, No. 9. pp. 1448-1453.
@article{2603984010b14fd8b6e46d283fbe1647,
title = "Reduced somatostatin-like immunoreactivity in cerebral cortex in nonfamilial dysphasic dementia",
abstract = "A nonfamilial syndrome is described in two middle-aged men who presented with progressive aphasia without incipient signs of cognitive impairment. In each case, 2 years elapsed before progressive functional decline or behavioral disabilities supervened. Radiologic studies documented asymmetric left cerebral atrophy that was progressive. The structure of the language disintegration was distinctive and not like that in Alzheimer's disease. Pathologic studies performed at postmortem examination of one patient documented asymmetric cerebral atrophy with nonspecific histopathologic changes. Biochemical studies revealed normal tissue levels of choline acetyltransferase activity, but reduced somatostatin-like immunoreactivity. Since cerebral somatostatin is largely present in intrinsic cortical neurons, while cholinergic innervation is largely derived from the basal forebrain, these findings suggest that nonfamilial dysphasic dementia may be an example of a distinct class of dementia due to intrinsic cortical degeneration, with sparing of the basal forebrain.",
author = "Mehler, {M. F.} and Horoupian, {D. S.} and P. Davies and Dickson, {Dennis W}",
year = "1987",
language = "English (US)",
volume = "37",
pages = "1448--1453",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Reduced somatostatin-like immunoreactivity in cerebral cortex in nonfamilial dysphasic dementia

AU - Mehler, M. F.

AU - Horoupian, D. S.

AU - Davies, P.

AU - Dickson, Dennis W

PY - 1987

Y1 - 1987

N2 - A nonfamilial syndrome is described in two middle-aged men who presented with progressive aphasia without incipient signs of cognitive impairment. In each case, 2 years elapsed before progressive functional decline or behavioral disabilities supervened. Radiologic studies documented asymmetric left cerebral atrophy that was progressive. The structure of the language disintegration was distinctive and not like that in Alzheimer's disease. Pathologic studies performed at postmortem examination of one patient documented asymmetric cerebral atrophy with nonspecific histopathologic changes. Biochemical studies revealed normal tissue levels of choline acetyltransferase activity, but reduced somatostatin-like immunoreactivity. Since cerebral somatostatin is largely present in intrinsic cortical neurons, while cholinergic innervation is largely derived from the basal forebrain, these findings suggest that nonfamilial dysphasic dementia may be an example of a distinct class of dementia due to intrinsic cortical degeneration, with sparing of the basal forebrain.

AB - A nonfamilial syndrome is described in two middle-aged men who presented with progressive aphasia without incipient signs of cognitive impairment. In each case, 2 years elapsed before progressive functional decline or behavioral disabilities supervened. Radiologic studies documented asymmetric left cerebral atrophy that was progressive. The structure of the language disintegration was distinctive and not like that in Alzheimer's disease. Pathologic studies performed at postmortem examination of one patient documented asymmetric cerebral atrophy with nonspecific histopathologic changes. Biochemical studies revealed normal tissue levels of choline acetyltransferase activity, but reduced somatostatin-like immunoreactivity. Since cerebral somatostatin is largely present in intrinsic cortical neurons, while cholinergic innervation is largely derived from the basal forebrain, these findings suggest that nonfamilial dysphasic dementia may be an example of a distinct class of dementia due to intrinsic cortical degeneration, with sparing of the basal forebrain.

UR - http://www.scopus.com/inward/record.url?scp=0023185376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023185376&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 1448

EP - 1453

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 9

ER -