Reduced risks of death and CHF are associated with statin therapy administered acutely within the first 24 h of AMI

R. Scott Wright, Kevin Bybee, Wayne L. Miller, Dennis A. Laudon, Joseph G. Murphy, Allan S Jaffe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Reports have demonstrated an association between statin therapy during the first day of hospitalization for acute myocardial infarction (AMI) and reduced mortality. There are little data about whether early statin therapy reduces risk of CHF and alters timing of death. Methods: We identified 3226 consecutive patients with AMI from 1993 through 2000 and divided them into early statin therapy (statins were administered within the initial 24 h of hospitalization, n = 220) and non-statin therapy groups (n = 3006). We compared mortality risks, rates of CHF development and measures of peak CK and CK-MB values between the groups. Results: In-hospital mortality was lower in the early statin therapy group (2.7%) compared to the non-statin therapy group (9.2%), p = 0.001. We observed no differences in the median time to death (statin group 132 h vs. non-statin group 72 h), p = 0.3. Patients with very early statin treatment had lower peak CK (624 ng/ml) and CK-MB (46 ng/ml) values compared to non-statin patients (848 ng/ml and 84 ng/ml), p < 0.01. Patients in the early statin group had lower risks of developing CHF during hospitalization (10.2 %) compared to the non-statin group (25.7%), p < 0.001. Conclusion: Very early administration of statin therapy during the first day of hospitalization for AMI was associated with lower in-hospital mortality, lower rates of developing CHF and reduced peak biomarker release. These data support a benefit from early statin therapy in AMI and support the need for prospective studies which test whether very early statin therapy might also reduce infarct size.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalInternational Journal of Cardiology
Volume108
Issue number3
DOIs
StatePublished - Apr 14 2006

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Myocardial Infarction
Secondary Prevention
Hospitalization
Therapeutics
Group Psychotherapy
Hospital Mortality
Mortality
Biomarkers

Keywords

  • Acute myocardial infarction
  • CHF
  • Statin theraphy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Reduced risks of death and CHF are associated with statin therapy administered acutely within the first 24 h of AMI. / Wright, R. Scott; Bybee, Kevin; Miller, Wayne L.; Laudon, Dennis A.; Murphy, Joseph G.; Jaffe, Allan S.

In: International Journal of Cardiology, Vol. 108, No. 3, 14.04.2006, p. 314-319.

Research output: Contribution to journalArticle

Wright, R. Scott ; Bybee, Kevin ; Miller, Wayne L. ; Laudon, Dennis A. ; Murphy, Joseph G. ; Jaffe, Allan S. / Reduced risks of death and CHF are associated with statin therapy administered acutely within the first 24 h of AMI. In: International Journal of Cardiology. 2006 ; Vol. 108, No. 3. pp. 314-319.
@article{7f8b3a2ed7f6467ab5b85e3fe067ffb2,
title = "Reduced risks of death and CHF are associated with statin therapy administered acutely within the first 24 h of AMI",
abstract = "Background: Reports have demonstrated an association between statin therapy during the first day of hospitalization for acute myocardial infarction (AMI) and reduced mortality. There are little data about whether early statin therapy reduces risk of CHF and alters timing of death. Methods: We identified 3226 consecutive patients with AMI from 1993 through 2000 and divided them into early statin therapy (statins were administered within the initial 24 h of hospitalization, n = 220) and non-statin therapy groups (n = 3006). We compared mortality risks, rates of CHF development and measures of peak CK and CK-MB values between the groups. Results: In-hospital mortality was lower in the early statin therapy group (2.7{\%}) compared to the non-statin therapy group (9.2{\%}), p = 0.001. We observed no differences in the median time to death (statin group 132 h vs. non-statin group 72 h), p = 0.3. Patients with very early statin treatment had lower peak CK (624 ng/ml) and CK-MB (46 ng/ml) values compared to non-statin patients (848 ng/ml and 84 ng/ml), p < 0.01. Patients in the early statin group had lower risks of developing CHF during hospitalization (10.2 {\%}) compared to the non-statin group (25.7{\%}), p < 0.001. Conclusion: Very early administration of statin therapy during the first day of hospitalization for AMI was associated with lower in-hospital mortality, lower rates of developing CHF and reduced peak biomarker release. These data support a benefit from early statin therapy in AMI and support the need for prospective studies which test whether very early statin therapy might also reduce infarct size.",
keywords = "Acute myocardial infarction, CHF, Statin theraphy",
author = "Wright, {R. Scott} and Kevin Bybee and Miller, {Wayne L.} and Laudon, {Dennis A.} and Murphy, {Joseph G.} and Jaffe, {Allan S}",
year = "2006",
month = "4",
day = "14",
doi = "10.1016/j.ijcard.2005.05.014",
language = "English (US)",
volume = "108",
pages = "314--319",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Reduced risks of death and CHF are associated with statin therapy administered acutely within the first 24 h of AMI

AU - Wright, R. Scott

AU - Bybee, Kevin

AU - Miller, Wayne L.

AU - Laudon, Dennis A.

AU - Murphy, Joseph G.

AU - Jaffe, Allan S

PY - 2006/4/14

Y1 - 2006/4/14

N2 - Background: Reports have demonstrated an association between statin therapy during the first day of hospitalization for acute myocardial infarction (AMI) and reduced mortality. There are little data about whether early statin therapy reduces risk of CHF and alters timing of death. Methods: We identified 3226 consecutive patients with AMI from 1993 through 2000 and divided them into early statin therapy (statins were administered within the initial 24 h of hospitalization, n = 220) and non-statin therapy groups (n = 3006). We compared mortality risks, rates of CHF development and measures of peak CK and CK-MB values between the groups. Results: In-hospital mortality was lower in the early statin therapy group (2.7%) compared to the non-statin therapy group (9.2%), p = 0.001. We observed no differences in the median time to death (statin group 132 h vs. non-statin group 72 h), p = 0.3. Patients with very early statin treatment had lower peak CK (624 ng/ml) and CK-MB (46 ng/ml) values compared to non-statin patients (848 ng/ml and 84 ng/ml), p < 0.01. Patients in the early statin group had lower risks of developing CHF during hospitalization (10.2 %) compared to the non-statin group (25.7%), p < 0.001. Conclusion: Very early administration of statin therapy during the first day of hospitalization for AMI was associated with lower in-hospital mortality, lower rates of developing CHF and reduced peak biomarker release. These data support a benefit from early statin therapy in AMI and support the need for prospective studies which test whether very early statin therapy might also reduce infarct size.

AB - Background: Reports have demonstrated an association between statin therapy during the first day of hospitalization for acute myocardial infarction (AMI) and reduced mortality. There are little data about whether early statin therapy reduces risk of CHF and alters timing of death. Methods: We identified 3226 consecutive patients with AMI from 1993 through 2000 and divided them into early statin therapy (statins were administered within the initial 24 h of hospitalization, n = 220) and non-statin therapy groups (n = 3006). We compared mortality risks, rates of CHF development and measures of peak CK and CK-MB values between the groups. Results: In-hospital mortality was lower in the early statin therapy group (2.7%) compared to the non-statin therapy group (9.2%), p = 0.001. We observed no differences in the median time to death (statin group 132 h vs. non-statin group 72 h), p = 0.3. Patients with very early statin treatment had lower peak CK (624 ng/ml) and CK-MB (46 ng/ml) values compared to non-statin patients (848 ng/ml and 84 ng/ml), p < 0.01. Patients in the early statin group had lower risks of developing CHF during hospitalization (10.2 %) compared to the non-statin group (25.7%), p < 0.001. Conclusion: Very early administration of statin therapy during the first day of hospitalization for AMI was associated with lower in-hospital mortality, lower rates of developing CHF and reduced peak biomarker release. These data support a benefit from early statin therapy in AMI and support the need for prospective studies which test whether very early statin therapy might also reduce infarct size.

KW - Acute myocardial infarction

KW - CHF

KW - Statin theraphy

UR - http://www.scopus.com/inward/record.url?scp=33644764024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644764024&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2005.05.014

DO - 10.1016/j.ijcard.2005.05.014

M3 - Article

C2 - 15975672

AN - SCOPUS:33644764024

VL - 108

SP - 314

EP - 319

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 3

ER -