Reduced platelet activity is associated with more intraventricular hemorrhage

Andrew M. Naidech, Bernard Bendok, Rajeev K. Garg, Richard A. Bernstein, Mark J. Alberts, Thomas P. Bleck, H. Hunt Batjer

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

OBJECTIVE: Intraventricular hemorrhage (IVH) is a serious complication of intracerebral hemorrhage (ICH). We hypothesized that antiplatelet medication use and platelet activity would be associated with more IVH. METHODS: We prospectively identified patients with spontaneous ICH and measured platelet activity on admission with the VerifyNow-Aspirin assay (Accumetrics, San Diego, CA). IVH volume was quantified with the Graeb scale, divided into categories of 0 (no IVH), 1 to 2 (minimal IVH), 3 to 5 (moderate IVH), and 6 and above (severe IVH). Antiplatelet medications were prospectively recorded. We used ordinal regression to measure the effect of platelet activity after correcting for ICH location and ICH volume. Outcomes were measured at 14 days or discharge with the National Institutes of Health Stroke Scale and modified Rankin Scale (mRS) and at 28 days and 3 months with the mRS. RESULTS: In our cohort of 73 patients, 36 had no IVH, 11 had minimal IVH, 10 had moderate IVH, and 16 had severe IVH. Aspirin and clopidogrel (P = 0.03 for both) were associated with less platelet activity. More IVH was related to reduced platelet activity (P = 0.01) after correction for ICH volume and location without contribution from aspirin or clopidogrel use. IVH was associated with worse National Institutes of Health Stroke Scale score (P = 0.002) and mRS score (P = 0.001) at 14 days and with mRS scores at 28 days (P = 0.02) and 3 months (P = 0.008). CONCLUSION: Reduced platelet activity was related to more IVH as a complication of ICH. The relationship of platelet activity to IVH deserves further study.

Original languageEnglish (US)
Pages (from-to)684-688
Number of pages5
JournalNeurosurgery
Volume65
Issue number4
DOIs
StatePublished - Oct 2009
Externally publishedYes

Fingerprint

Blood Platelets
Hemorrhage
Cerebral Hemorrhage
clopidogrel
Aspirin
National Institutes of Health (U.S.)
Stroke

Keywords

  • Intracerebral hemorrhage
  • Intraventricular hemorrhage
  • Outcomes
  • Platelets

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Naidech, A. M., Bendok, B., Garg, R. K., Bernstein, R. A., Alberts, M. J., Bleck, T. P., & Batjer, H. H. (2009). Reduced platelet activity is associated with more intraventricular hemorrhage. Neurosurgery, 65(4), 684-688. https://doi.org/10.1227/01.NEU.0000351769.39990.16

Reduced platelet activity is associated with more intraventricular hemorrhage. / Naidech, Andrew M.; Bendok, Bernard; Garg, Rajeev K.; Bernstein, Richard A.; Alberts, Mark J.; Bleck, Thomas P.; Batjer, H. Hunt.

In: Neurosurgery, Vol. 65, No. 4, 10.2009, p. 684-688.

Research output: Contribution to journalArticle

Naidech, AM, Bendok, B, Garg, RK, Bernstein, RA, Alberts, MJ, Bleck, TP & Batjer, HH 2009, 'Reduced platelet activity is associated with more intraventricular hemorrhage', Neurosurgery, vol. 65, no. 4, pp. 684-688. https://doi.org/10.1227/01.NEU.0000351769.39990.16
Naidech, Andrew M. ; Bendok, Bernard ; Garg, Rajeev K. ; Bernstein, Richard A. ; Alberts, Mark J. ; Bleck, Thomas P. ; Batjer, H. Hunt. / Reduced platelet activity is associated with more intraventricular hemorrhage. In: Neurosurgery. 2009 ; Vol. 65, No. 4. pp. 684-688.
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AU - Naidech, Andrew M.

AU - Bendok, Bernard

AU - Garg, Rajeev K.

AU - Bernstein, Richard A.

AU - Alberts, Mark J.

AU - Bleck, Thomas P.

AU - Batjer, H. Hunt

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N2 - OBJECTIVE: Intraventricular hemorrhage (IVH) is a serious complication of intracerebral hemorrhage (ICH). We hypothesized that antiplatelet medication use and platelet activity would be associated with more IVH. METHODS: We prospectively identified patients with spontaneous ICH and measured platelet activity on admission with the VerifyNow-Aspirin assay (Accumetrics, San Diego, CA). IVH volume was quantified with the Graeb scale, divided into categories of 0 (no IVH), 1 to 2 (minimal IVH), 3 to 5 (moderate IVH), and 6 and above (severe IVH). Antiplatelet medications were prospectively recorded. We used ordinal regression to measure the effect of platelet activity after correcting for ICH location and ICH volume. Outcomes were measured at 14 days or discharge with the National Institutes of Health Stroke Scale and modified Rankin Scale (mRS) and at 28 days and 3 months with the mRS. RESULTS: In our cohort of 73 patients, 36 had no IVH, 11 had minimal IVH, 10 had moderate IVH, and 16 had severe IVH. Aspirin and clopidogrel (P = 0.03 for both) were associated with less platelet activity. More IVH was related to reduced platelet activity (P = 0.01) after correction for ICH volume and location without contribution from aspirin or clopidogrel use. IVH was associated with worse National Institutes of Health Stroke Scale score (P = 0.002) and mRS score (P = 0.001) at 14 days and with mRS scores at 28 days (P = 0.02) and 3 months (P = 0.008). CONCLUSION: Reduced platelet activity was related to more IVH as a complication of ICH. The relationship of platelet activity to IVH deserves further study.

AB - OBJECTIVE: Intraventricular hemorrhage (IVH) is a serious complication of intracerebral hemorrhage (ICH). We hypothesized that antiplatelet medication use and platelet activity would be associated with more IVH. METHODS: We prospectively identified patients with spontaneous ICH and measured platelet activity on admission with the VerifyNow-Aspirin assay (Accumetrics, San Diego, CA). IVH volume was quantified with the Graeb scale, divided into categories of 0 (no IVH), 1 to 2 (minimal IVH), 3 to 5 (moderate IVH), and 6 and above (severe IVH). Antiplatelet medications were prospectively recorded. We used ordinal regression to measure the effect of platelet activity after correcting for ICH location and ICH volume. Outcomes were measured at 14 days or discharge with the National Institutes of Health Stroke Scale and modified Rankin Scale (mRS) and at 28 days and 3 months with the mRS. RESULTS: In our cohort of 73 patients, 36 had no IVH, 11 had minimal IVH, 10 had moderate IVH, and 16 had severe IVH. Aspirin and clopidogrel (P = 0.03 for both) were associated with less platelet activity. More IVH was related to reduced platelet activity (P = 0.01) after correction for ICH volume and location without contribution from aspirin or clopidogrel use. IVH was associated with worse National Institutes of Health Stroke Scale score (P = 0.002) and mRS score (P = 0.001) at 14 days and with mRS scores at 28 days (P = 0.02) and 3 months (P = 0.008). CONCLUSION: Reduced platelet activity was related to more IVH as a complication of ICH. The relationship of platelet activity to IVH deserves further study.

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