Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor

S. Bevan; S. Heinemann; V. A. Lennon; J. Lindstrom

doi:10.1038/260438a0

Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor

S. Bevan, S. Heinemann, V. A. Lennon, J. Lindstrom

Laboratory Medicine and Pathology

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Abstract

ANIMALS immunised with acetylcholine receptor (AChR) purified from the electric organ of Electrophorus electricus or Torpedo marmorata develop a muscular weakness which is alleviated by injections of anticholinesterases ^1-6. This observation has provided a valuable animal model for study of the disease myasthenia gravis. Sera from rats immunised with electric eel receptor contain antibody to AChR isolated from rat skeletal muscle ^2,6, suggesting that the muscular weakness is due to a reduced endplate sensitivity to ACh. We report here a reduction in the ACh sensitivity of denervated muscles from immunised rats. Furthermore, there is a factor in the serum of immunised rats which can reduce the ACh sensitivity of denervated rat muscles in vitro.

Original language	English (US)
Pages (from-to)	438-439
Number of pages	2
Journal	Nature
Volume	260
Issue number	5550
DOIs	https://doi.org/10.1038/260438a0
State	Published - 1976

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abstract = "ANIMALS immunised with acetylcholine receptor (AChR) purified from the electric organ of Electrophorus electricus or Torpedo marmorata develop a muscular weakness which is alleviated by injections of anticholinesterases 1-6. This observation has provided a valuable animal model for study of the disease myasthenia gravis. Sera from rats immunised with electric eel receptor contain antibody to AChR isolated from rat skeletal muscle 2,6, suggesting that the muscular weakness is due to a reduced endplate sensitivity to ACh. We report here a reduction in the ACh sensitivity of denervated muscles from immunised rats. Furthermore, there is a factor in the serum of immunised rats which can reduce the ACh sensitivity of denervated rat muscles in vitro.",

author = "S. Bevan and S. Heinemann and Lennon, {V. A.} and J. Lindstrom",

year = "1976",

doi = "10.1038/260438a0",

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AU - Bevan, S.

AU - Heinemann, S.

AU - Lennon, V. A.

AU - Lindstrom, J.

PY - 1976

Y1 - 1976

N2 - ANIMALS immunised with acetylcholine receptor (AChR) purified from the electric organ of Electrophorus electricus or Torpedo marmorata develop a muscular weakness which is alleviated by injections of anticholinesterases 1-6. This observation has provided a valuable animal model for study of the disease myasthenia gravis. Sera from rats immunised with electric eel receptor contain antibody to AChR isolated from rat skeletal muscle 2,6, suggesting that the muscular weakness is due to a reduced endplate sensitivity to ACh. We report here a reduction in the ACh sensitivity of denervated muscles from immunised rats. Furthermore, there is a factor in the serum of immunised rats which can reduce the ACh sensitivity of denervated rat muscles in vitro.

AB - ANIMALS immunised with acetylcholine receptor (AChR) purified from the electric organ of Electrophorus electricus or Torpedo marmorata develop a muscular weakness which is alleviated by injections of anticholinesterases 1-6. This observation has provided a valuable animal model for study of the disease myasthenia gravis. Sera from rats immunised with electric eel receptor contain antibody to AChR isolated from rat skeletal muscle 2,6, suggesting that the muscular weakness is due to a reduced endplate sensitivity to ACh. We report here a reduction in the ACh sensitivity of denervated muscles from immunised rats. Furthermore, there is a factor in the serum of immunised rats which can reduce the ACh sensitivity of denervated rat muscles in vitro.

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Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor

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