Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor

S. Bevan, S. Heinemann, Vanda A Lennon, J. Lindstrom

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Animals immunised with acetylcholine receptor (AChR) purified from the electric organ of Electrophorus electricus or Torpedo marmorata develop a muscular weakness which is alleviated by injections of anticholinesterases. This observation has provided a valuable animal model for study of the disease myasthenia gravis. Sera from rats immunised with electric eel receptor contain antibody to AChR isolated from rat skeletal muscle, suggesting that the muscular weakness is due to a reduced endplate sensitivity to ACh. The authors report here a reduction in the ACh sensitivity of denervated muscles from immunised rats. Furthermore, there is a factor in the serum of immunised rats which can reduce the ACh sensitivity of denervated rat muscles in vitro.

Original languageEnglish (US)
Pages (from-to)438-439
Number of pages2
JournalNature
Volume260
Issue number5550
StatePublished - 1976
Externally publishedYes

Fingerprint

Cholinergic Receptors
Acetylcholine
Muscles
Electrophorus
Muscle Weakness
Electric Organ
Animal Disease Models
Torpedo
Myasthenia Gravis
Cholinesterase Inhibitors
Serum
Skeletal Muscle
Injections
Antibodies

ASJC Scopus subject areas

  • General

Cite this

Bevan, S., Heinemann, S., Lennon, V. A., & Lindstrom, J. (1976). Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor. Nature, 260(5550), 438-439.

Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor. / Bevan, S.; Heinemann, S.; Lennon, Vanda A; Lindstrom, J.

In: Nature, Vol. 260, No. 5550, 1976, p. 438-439.

Research output: Contribution to journalArticle

Bevan, S, Heinemann, S, Lennon, VA & Lindstrom, J 1976, 'Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor', Nature, vol. 260, no. 5550, pp. 438-439.
Bevan, S. ; Heinemann, S. ; Lennon, Vanda A ; Lindstrom, J. / Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor. In: Nature. 1976 ; Vol. 260, No. 5550. pp. 438-439.
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