Reduced leg blood flow during dynamic exercise in older endurance- trained men

David N. Proctor, Peter H. Shen, Niki M. Dietz, Tamara J. Eickhoff, Lori A. Lawler, Ethan J. Ebersold, Darrell L. Loeffler, Michael Joseph Joyner

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Abstract

It is currently unclear whether aging alters the perfusion of active muscles during large-muscle dynamic exercise in humans. To study this issue, direct measurements of leg blood flow (femoral vein thermodilution) and systemic arterial pressure during submaximal cycle ergometry (70, 140, and 210 W) were compared between six younger (Y; 22-30 yr) and six older (O; 55- 68 yr) chronically endurance-trained men. Whole body O2 uptake, ventilation, and arterial and femoral venous samples for blood-gas, catecholamine, and lactate determinations were also obtained. Training duration (min/day), estimated leg muscle mass (dual-energy X-ray absorptiometry; Y, 21.5 ± 1.2 vs. O, 19.9 ± 0.9 kg), and blood hemoglobin concentration (Y, 14.9 ± 0.4 vs. O, 14.7 ± 0.2 g/dl) did not significantly differ (P > 0.05) between groups. Leg blood flow, leg vascular conductance, and femoral venous O2 saturation were ~20-30% lower in the older men at each work rate (all P < 0.05), despite similar levels of whole body O2 uptake. At 210 W, leg norepinephrine spillover rates and femoral venous lactate concentrations were more than twofold higher in the older men. Pulmonary ventilation was also higher in the older men at 140 (+24%) and 210 (+39%) W. These results indicate that leg blood flow and vascular conductance during cycle ergometer exercise are significantly lower in older endurance-trained men in comparison to their younger counterparts. The mechanisms responsible for this phenomenon and the extent to which they operate in other groups of older subjects deserve further attention.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalJournal of Applied Physiology
Volume85
Issue number1
StatePublished - Jul 1998

Fingerprint

Leg
Exercise
Thigh
Muscles
Blood Vessels
Lactic Acid
Ergometry
Thermodilution
Pulmonary Ventilation
Femoral Vein
Photon Absorptiometry
Catecholamines
Ventilation
Norepinephrine
Arterial Pressure
Hemoglobins
Perfusion
Gases

Keywords

  • Catecholamines
  • Exercise hyperemia
  • Master athlete
  • Respiratory muscles

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Proctor, D. N., Shen, P. H., Dietz, N. M., Eickhoff, T. J., Lawler, L. A., Ebersold, E. J., ... Joyner, M. J. (1998). Reduced leg blood flow during dynamic exercise in older endurance- trained men. Journal of Applied Physiology, 85(1), 68-75.

Reduced leg blood flow during dynamic exercise in older endurance- trained men. / Proctor, David N.; Shen, Peter H.; Dietz, Niki M.; Eickhoff, Tamara J.; Lawler, Lori A.; Ebersold, Ethan J.; Loeffler, Darrell L.; Joyner, Michael Joseph.

In: Journal of Applied Physiology, Vol. 85, No. 1, 07.1998, p. 68-75.

Research output: Contribution to journalArticle

Proctor, DN, Shen, PH, Dietz, NM, Eickhoff, TJ, Lawler, LA, Ebersold, EJ, Loeffler, DL & Joyner, MJ 1998, 'Reduced leg blood flow during dynamic exercise in older endurance- trained men', Journal of Applied Physiology, vol. 85, no. 1, pp. 68-75.
Proctor DN, Shen PH, Dietz NM, Eickhoff TJ, Lawler LA, Ebersold EJ et al. Reduced leg blood flow during dynamic exercise in older endurance- trained men. Journal of Applied Physiology. 1998 Jul;85(1):68-75.
Proctor, David N. ; Shen, Peter H. ; Dietz, Niki M. ; Eickhoff, Tamara J. ; Lawler, Lori A. ; Ebersold, Ethan J. ; Loeffler, Darrell L. ; Joyner, Michael Joseph. / Reduced leg blood flow during dynamic exercise in older endurance- trained men. In: Journal of Applied Physiology. 1998 ; Vol. 85, No. 1. pp. 68-75.
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