Reduced hippocampal functional connectivity in Alzheimer disease

Greg Allen; Holly Barnard; Roderick McColl; Andrea L. Hester; Julie A. Fields; Myron F. Weiner; Wendy K. Ringe; Anne M. Lipton; Matthew Brooker; Elizabeth McDonald; Craig D. Rubin; C. Munro Cullum

doi:10.1001/archneur.64.10.1482

Reduced hippocampal functional connectivity in Alzheimer disease

Greg Allen, Holly Barnard, Roderick McColl, Andrea L. Hester, Julie A. Fields, Myron F. Weiner, Wendy K. Ringe, Anne M. Lipton, Matthew Brooker, Elizabeth McDonald, Craig D. Rubin, C. Munro Cullum

Psychiatry and Psychology

Research output: Contribution to journal › Article › peer-review

225 Scopus citations

Abstract

Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease. Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain. Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers. Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes. Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.

Original language	English (US)
Pages (from-to)	1482-1487
Number of pages	6
Journal	Archives of neurology
Volume	64
Issue number	10
DOIs	https://doi.org/10.1001/archneur.64.10.1482
State	Published - Oct 2007

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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title = "Reduced hippocampal functional connectivity in Alzheimer disease",

abstract = "Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease. Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain. Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers. Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes. Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.",

author = "Greg Allen and Holly Barnard and Roderick McColl and Hester, {Andrea L.} and Fields, {Julie A.} and Weiner, {Myron F.} and Ringe, {Wendy K.} and Lipton, {Anne M.} and Matthew Brooker and Elizabeth McDonald and Rubin, {Craig D.} and Cullum, {C. Munro}",

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doi = "10.1001/archneur.64.10.1482",

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T1 - Reduced hippocampal functional connectivity in Alzheimer disease

AU - Allen, Greg

AU - Barnard, Holly

AU - McColl, Roderick

AU - Hester, Andrea L.

AU - Fields, Julie A.

AU - Weiner, Myron F.

AU - Ringe, Wendy K.

AU - Lipton, Anne M.

AU - Brooker, Matthew

AU - McDonald, Elizabeth

AU - Rubin, Craig D.

AU - Cullum, C. Munro

PY - 2007/10

Y1 - 2007/10

N2 - Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease. Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain. Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers. Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes. Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.

AB - Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease. Design: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain. Participants: Eight patients with probable Alzheimer disease and 8 healthy volunteers. Results: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes. Conclusion: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.

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Reduced hippocampal functional connectivity in Alzheimer disease

Abstract

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