Reduced axoplasmic transport of choline acetyltransferase activity in dystrophic mice

Charles Jablecki, Stephen Brimijoin

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

MUSCULAR dystrophy has been regarded as a "primary degenerative myopathy"1. But there is evidence from studies of both human muscular dystrophy and animal models of muscular dystrophy that the muscle disease may have a neural basis2. The mechanism of the suspected neural disorder remains to be elucidated. Since there is independent evidence that in normal animals the trophic effect of nerve on muscle depends on intact axoplasmic transport3, we have initiated a study of axoplasmic transport in dystrophic mice. We have found a disturbance of axoplasmic transport of choline acetyltransferase activity in dystrophic mice.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalNature
Volume250
Issue number5462
DOIs
StatePublished - Dec 1 1974

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