Reduced axoplasmic transport of choline acetyltransferase activity in dystrophic mice

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Abstract

The choline acetyltransferase (CAT) activity of dystrophic muscle has been shown to be reduced compared with normal muscle. The reduction in dystrophic muscle CAT activity may be related to the reduction in axoplasmic transport of CAT activity which is reported. Whether reduced axoplasmic transport of CAT activity is actually involved in the pathogenesis of the muscle abnormalities in murine muscular dystrophy remains to be determined. The neural abnormalities in dystrophic mice may be independent of the muscle disease. But as previously mentioned, there is evidence that the trophic effect of nerve on muscle depends on intact axoplasmic transport. Therefore, it is possible that the muscle disease in dystrophic mice may be related to a disturbance of the axoplasmic transport of motor (cholinergic) neurones.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalNature
Volume250
Issue number5462
StatePublished - 1974

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Axonal Transport
Choline O-Acetyltransferase
Muscles
Cholinergic Neurons
Muscular Dystrophies
Motor Neurons

ASJC Scopus subject areas

  • General

Cite this

Reduced axoplasmic transport of choline acetyltransferase activity in dystrophic mice. / Jablecki, C.; Brimijoin, William Stephen.

In: Nature, Vol. 250, No. 5462, 1974, p. 151-154.

Research output: Contribution to journalArticle

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