Reduced axoplasmic transport of choline acetyltransferase activity in dystrophic mice

MUSCULAR dystrophy has been regarded as a "primary degenerative myopathy"¹. But there is evidence from studies of both human muscular dystrophy and animal models of muscular dystrophy that the muscle disease may have a neural basis². The mechanism of the suspected neural disorder remains to be elucidated. Since there is independent evidence that in normal animals the trophic effect of nerve on muscle depends on intact axoplasmic transport³, we have initiated a study of axoplasmic transport in dystrophic mice. We have found a disturbance of axoplasmic transport of choline acetyltransferase activity in dystrophic mice.