Redox events in HTLV-1 tax-induced apoptotic T-cell death

Katerina Chlichlia, Marek Los, Klaus Schulze-Osthoff, Louis Gazzolo, Volker Schirrmacher, Khashayarsha Khazaie

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A number of studies implicate reactive oxygen intermediates in the induction of DNA damage and apoptosis. Recent studies suggest that the human T-cell leukemia virus type 1 (HTLV-1) Tax protein induces oxidative stress and apoptotic T-cell death. Activation of the T-cell receptor/CD3 pathway enhances the Tax-mediated oxidative and apoptotic effects. Tax-mediated apoptosis and oxidative stress as well as activation of nuclear factor-KB can be potently suppressed by antioxidants. This review focuses on Tax-dependent changes in the intracellular redox status and their role in Tax-mediated DNA damage and apoptosis. The relevance of these observations to HTLV-1 virus-mediated T-cell transformation and leukemogenesis are discussed.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalAntioxidants and Redox Signaling
Volume4
Issue number3
StatePublished - 2002
Externally publishedYes

Fingerprint

Deltaretrovirus
T-cells
Cell death
Taxation
Viruses
Oxidation-Reduction
Cell Death
Apoptosis
T-Lymphocytes
DNA Damage
Oxidative stress
Oxidative Stress
tax Gene Products
Chemical activation
T-Cell Antigen Receptor
DNA
Antioxidants
Oxygen

ASJC Scopus subject areas

  • Biochemistry

Cite this

Chlichlia, K., Los, M., Schulze-Osthoff, K., Gazzolo, L., Schirrmacher, V., & Khazaie, K. (2002). Redox events in HTLV-1 tax-induced apoptotic T-cell death. Antioxidants and Redox Signaling, 4(3), 471-477.

Redox events in HTLV-1 tax-induced apoptotic T-cell death. / Chlichlia, Katerina; Los, Marek; Schulze-Osthoff, Klaus; Gazzolo, Louis; Schirrmacher, Volker; Khazaie, Khashayarsha.

In: Antioxidants and Redox Signaling, Vol. 4, No. 3, 2002, p. 471-477.

Research output: Contribution to journalArticle

Chlichlia, K, Los, M, Schulze-Osthoff, K, Gazzolo, L, Schirrmacher, V & Khazaie, K 2002, 'Redox events in HTLV-1 tax-induced apoptotic T-cell death', Antioxidants and Redox Signaling, vol. 4, no. 3, pp. 471-477.
Chlichlia K, Los M, Schulze-Osthoff K, Gazzolo L, Schirrmacher V, Khazaie K. Redox events in HTLV-1 tax-induced apoptotic T-cell death. Antioxidants and Redox Signaling. 2002;4(3):471-477.
Chlichlia, Katerina ; Los, Marek ; Schulze-Osthoff, Klaus ; Gazzolo, Louis ; Schirrmacher, Volker ; Khazaie, Khashayarsha. / Redox events in HTLV-1 tax-induced apoptotic T-cell death. In: Antioxidants and Redox Signaling. 2002 ; Vol. 4, No. 3. pp. 471-477.
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