Redox events in HTLV-1 tax-induced apoptotic T-cell death

Katerina Chlichlia, Marek Los, Klaus Schulze-Osthoff, Louis Gazzolo, Volker Schirrmacher, Khashayarsha Khazaie

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

A number of studies implicate reactive oxygen intermediates in the induction of DNA damage and apoptosis. Recent studies suggest that the human T-cell leukemia virus type 1 (HTLV-1) Tax protein induces oxidative stress and apoptotic T-cell death. Activation of the T-cell receptor/CD3 pathway enhances the Tax-mediated oxidative and apoptotic effects. Tax-mediated apoptosis and oxidative stress as well as activation of nuclear factor-KB can be potently suppressed by antioxidants. This review focuses on Tax-dependent changes in the intracellular redox status and their role in Tax-mediated DNA damage and apoptosis. The relevance of these observations to HTLV-1 virus-mediated T-cell transformation and leukemogenesis are discussed.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalAntioxidants and Redox Signaling
Volume4
Issue number3
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Redox events in HTLV-1 tax-induced apoptotic T-cell death'. Together they form a unique fingerprint.

  • Cite this

    Chlichlia, K., Los, M., Schulze-Osthoff, K., Gazzolo, L., Schirrmacher, V., & Khazaie, K. (2002). Redox events in HTLV-1 tax-induced apoptotic T-cell death. Antioxidants and Redox Signaling, 4(3), 471-477. https://doi.org/10.1089/15230860260196263