Red cell mass and plasma volume measurements in polycythemia: Evaluation of performance and practical utility

Shireen Sirhan, Virgil F. Fairbanks, Ayalew Tefferi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

BACKGROUND. Despite the absence of any systematic evidence for diagnostic utility, red cell mass (RCM) measurement has been endorsed as a major diagnostic criterion for polycythemia vera (PV) based on a set of eligibility criteria for a clinical trial formulated by an International PV Study Group in 1967. METHODS. A retrospective analysis was performed on a consecutive series of 105 patients who underwent blood volume measurements for evaluation of polycythemia. In a previous study, the authors had systematically compared RCM measurement by 51Cr-labeled eiythrocytes and 125I-labeled human serum albumin and demonstrated equivalence between the two methods. In the current study, they used the latter method and applied the International Committee for Standardization in Haematology recommendations for result interpretation in order to evaluate test performance and practical utility. RESULTS. RCM exceeded the 98-99% limits of the reference range in 76%, 20%, 22%, and 57% of patients with PV (n = 25), secondary polycythemia (n = 35), spurious or apparent polycythemia (n = 38), and essential thrombocythemia (n = 7), respectively. Decreased plasma volume was rarely seen in any of the disease categories. In all instances of PV, the diagnosis was readily apparent, based on alternative clinical and laboratory tests, and did not require the additional information from blood volume measurement. Furthermore, alternative methods of PV diagnosis, based on disease-specific biological markers as well as bone marrow histology, are now available. CONCLUSIONS. The continued use of RCM and plasma volume measurements for the diagnosis of PV is no longer warranted.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalCancer
Volume104
Issue number1
DOIs
StatePublished - Jul 1 2005

Fingerprint

Erythrocyte Volume
Polycythemia Vera
Polycythemia
Plasma Volume
Cell Size
Blood Volume
Essential Thrombocythemia
Hematology
Serum Albumin
Histology
Reference Values
Biomarkers
Bone Marrow
Clinical Trials

Keywords

  • Plasma volume
  • Polycythemia
  • Practical utility
  • Red cell mass

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Red cell mass and plasma volume measurements in polycythemia : Evaluation of performance and practical utility. / Sirhan, Shireen; Fairbanks, Virgil F.; Tefferi, Ayalew.

In: Cancer, Vol. 104, No. 1, 01.07.2005, p. 213-215.

Research output: Contribution to journalArticle

@article{276cdbf201c8490cb430326b85ad925a,
title = "Red cell mass and plasma volume measurements in polycythemia: Evaluation of performance and practical utility",
abstract = "BACKGROUND. Despite the absence of any systematic evidence for diagnostic utility, red cell mass (RCM) measurement has been endorsed as a major diagnostic criterion for polycythemia vera (PV) based on a set of eligibility criteria for a clinical trial formulated by an International PV Study Group in 1967. METHODS. A retrospective analysis was performed on a consecutive series of 105 patients who underwent blood volume measurements for evaluation of polycythemia. In a previous study, the authors had systematically compared RCM measurement by 51Cr-labeled eiythrocytes and 125I-labeled human serum albumin and demonstrated equivalence between the two methods. In the current study, they used the latter method and applied the International Committee for Standardization in Haematology recommendations for result interpretation in order to evaluate test performance and practical utility. RESULTS. RCM exceeded the 98-99{\%} limits of the reference range in 76{\%}, 20{\%}, 22{\%}, and 57{\%} of patients with PV (n = 25), secondary polycythemia (n = 35), spurious or apparent polycythemia (n = 38), and essential thrombocythemia (n = 7), respectively. Decreased plasma volume was rarely seen in any of the disease categories. In all instances of PV, the diagnosis was readily apparent, based on alternative clinical and laboratory tests, and did not require the additional information from blood volume measurement. Furthermore, alternative methods of PV diagnosis, based on disease-specific biological markers as well as bone marrow histology, are now available. CONCLUSIONS. The continued use of RCM and plasma volume measurements for the diagnosis of PV is no longer warranted.",
keywords = "Plasma volume, Polycythemia, Practical utility, Red cell mass",
author = "Shireen Sirhan and Fairbanks, {Virgil F.} and Ayalew Tefferi",
year = "2005",
month = "7",
day = "1",
doi = "10.1002/cncr.21105",
language = "English (US)",
volume = "104",
pages = "213--215",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Red cell mass and plasma volume measurements in polycythemia

T2 - Evaluation of performance and practical utility

AU - Sirhan, Shireen

AU - Fairbanks, Virgil F.

AU - Tefferi, Ayalew

PY - 2005/7/1

Y1 - 2005/7/1

N2 - BACKGROUND. Despite the absence of any systematic evidence for diagnostic utility, red cell mass (RCM) measurement has been endorsed as a major diagnostic criterion for polycythemia vera (PV) based on a set of eligibility criteria for a clinical trial formulated by an International PV Study Group in 1967. METHODS. A retrospective analysis was performed on a consecutive series of 105 patients who underwent blood volume measurements for evaluation of polycythemia. In a previous study, the authors had systematically compared RCM measurement by 51Cr-labeled eiythrocytes and 125I-labeled human serum albumin and demonstrated equivalence between the two methods. In the current study, they used the latter method and applied the International Committee for Standardization in Haematology recommendations for result interpretation in order to evaluate test performance and practical utility. RESULTS. RCM exceeded the 98-99% limits of the reference range in 76%, 20%, 22%, and 57% of patients with PV (n = 25), secondary polycythemia (n = 35), spurious or apparent polycythemia (n = 38), and essential thrombocythemia (n = 7), respectively. Decreased plasma volume was rarely seen in any of the disease categories. In all instances of PV, the diagnosis was readily apparent, based on alternative clinical and laboratory tests, and did not require the additional information from blood volume measurement. Furthermore, alternative methods of PV diagnosis, based on disease-specific biological markers as well as bone marrow histology, are now available. CONCLUSIONS. The continued use of RCM and plasma volume measurements for the diagnosis of PV is no longer warranted.

AB - BACKGROUND. Despite the absence of any systematic evidence for diagnostic utility, red cell mass (RCM) measurement has been endorsed as a major diagnostic criterion for polycythemia vera (PV) based on a set of eligibility criteria for a clinical trial formulated by an International PV Study Group in 1967. METHODS. A retrospective analysis was performed on a consecutive series of 105 patients who underwent blood volume measurements for evaluation of polycythemia. In a previous study, the authors had systematically compared RCM measurement by 51Cr-labeled eiythrocytes and 125I-labeled human serum albumin and demonstrated equivalence between the two methods. In the current study, they used the latter method and applied the International Committee for Standardization in Haematology recommendations for result interpretation in order to evaluate test performance and practical utility. RESULTS. RCM exceeded the 98-99% limits of the reference range in 76%, 20%, 22%, and 57% of patients with PV (n = 25), secondary polycythemia (n = 35), spurious or apparent polycythemia (n = 38), and essential thrombocythemia (n = 7), respectively. Decreased plasma volume was rarely seen in any of the disease categories. In all instances of PV, the diagnosis was readily apparent, based on alternative clinical and laboratory tests, and did not require the additional information from blood volume measurement. Furthermore, alternative methods of PV diagnosis, based on disease-specific biological markers as well as bone marrow histology, are now available. CONCLUSIONS. The continued use of RCM and plasma volume measurements for the diagnosis of PV is no longer warranted.

KW - Plasma volume

KW - Polycythemia

KW - Practical utility

KW - Red cell mass

UR - http://www.scopus.com/inward/record.url?scp=20544457318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20544457318&partnerID=8YFLogxK

U2 - 10.1002/cncr.21105

DO - 10.1002/cncr.21105

M3 - Article

C2 - 15889449

AN - SCOPUS:20544457318

VL - 104

SP - 213

EP - 215

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 1

ER -