Red blood cell storage lesion

Daryl J Kor, Camille M. Van Buskirk, Ognjen Gajic

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The past two decades have witnessed increased scrutiny regarding efficacy and risk of the once unquestioned therapy of red blood cell RBC transfusion. Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with reduced tissue oxygenation and transfusion-associated adverse effects. These alterations are collectively termed the storage lesion and include extensive biochemical, biomechanical, and immunologic changes involving cells of diverse origin. Time-dependent falls is 2,3-diphosphoglycerate, intracellular RBC adenosine triphosphate, and nitric oxide have been shown to impact RBC deformability and delivery of oxygen to the end-organ. The accumulation of biologic response modifiers such as soluble CD40 ligand sCD4oL, lyso-phosphatidylcholine lyso-PC, and Regulated on Activation, Normal T-cell Expressed and Secreted RANTES have been associated with altered recipient immune function as well. This review will address the alterations occurring within the RBC and storage media during RBC preservation and will address the potential clinical consequence thereof.

Original languageEnglish (US)
JournalBosnian Journal of Basic Medical Sciences
Volume9
Issue numberSUPPL.
StatePublished - 2009

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2,3-Diphosphoglycerate
Erythrocyte Transfusion
Chemokine CCL5
CD40 Ligand
Phosphatidylcholines
Nitric Oxide
Adenosine Triphosphate
Erythrocytes
Oxygen
T-Lymphocytes
Therapeutics

Keywords

  • Red blood cell transfusion
  • Storage lesion
  • Transfusion efficacy
  • Transfusion risks

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Red blood cell storage lesion. / Kor, Daryl J; Van Buskirk, Camille M.; Gajic, Ognjen.

In: Bosnian Journal of Basic Medical Sciences, Vol. 9, No. SUPPL., 2009.

Research output: Contribution to journalArticle

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