TY - JOUR
T1 - Red blood cell storage lesion
AU - Kor, Daryl J.
AU - Van Buskirk, Camille M.
AU - Gajic, Ognjen
PY - 2009
Y1 - 2009
N2 - The past two decades have witnessed increased scrutiny regarding efficacy and risk of the once unquestioned therapy of red blood cell RBC transfusion. Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with reduced tissue oxygenation and transfusion-associated adverse effects. These alterations are collectively termed the storage lesion and include extensive biochemical, biomechanical, and immunologic changes involving cells of diverse origin. Time-dependent falls is 2,3-diphosphoglycerate, intracellular RBC adenosine triphosphate, and nitric oxide have been shown to impact RBC deformability and delivery of oxygen to the end-organ. The accumulation of biologic response modifiers such as soluble CD40 ligand sCD4oL, lyso-phosphatidylcholine lyso-PC, and Regulated on Activation, Normal T-cell Expressed and Secreted RANTES have been associated with altered recipient immune function as well. This review will address the alterations occurring within the RBC and storage media during RBC preservation and will address the potential clinical consequence thereof.
AB - The past two decades have witnessed increased scrutiny regarding efficacy and risk of the once unquestioned therapy of red blood cell RBC transfusion. Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with reduced tissue oxygenation and transfusion-associated adverse effects. These alterations are collectively termed the storage lesion and include extensive biochemical, biomechanical, and immunologic changes involving cells of diverse origin. Time-dependent falls is 2,3-diphosphoglycerate, intracellular RBC adenosine triphosphate, and nitric oxide have been shown to impact RBC deformability and delivery of oxygen to the end-organ. The accumulation of biologic response modifiers such as soluble CD40 ligand sCD4oL, lyso-phosphatidylcholine lyso-PC, and Regulated on Activation, Normal T-cell Expressed and Secreted RANTES have been associated with altered recipient immune function as well. This review will address the alterations occurring within the RBC and storage media during RBC preservation and will address the potential clinical consequence thereof.
KW - Red blood cell transfusion
KW - Storage lesion
KW - Transfusion efficacy
KW - Transfusion risks
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U2 - 10.17305/bjbms.2009.2750
DO - 10.17305/bjbms.2009.2750
M3 - Article
C2 - 19912115
AN - SCOPUS:73949129832
SN - 1512-8601
VL - 9
SP - S21-S26
JO - Bosnian journal of basic medical sciences
JF - Bosnian journal of basic medical sciences
IS - SUPPL.
ER -