Recurrent thrombotic thrombocytopenic purpura (TTP) as a complication of acute relapsing pancreatitis

Jayant A. Talwalkar, Frederick W. Ruymann, Paul Marcoux, Francis A. Farraye

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pancreatitis is a known complication of thrombotic thrombocytopenic purpura (TTP) found in approximately 2% of cases. The development of TTP as a clinical sequelae of acute pancreatitis has also been reported, including one patient with chronic pancreatitis who developed TTP on two occasions following acute exacerbations of pancreatitis. We describe a case in which multiple distinct episodes of TTP have followed the clinical and laboratory demonstration of acute pancreatitis in the same patient. Supportive care of the patient's pancreatitis and plasmapheresis in each case resulted in clinical improvement and resolution of TTP. While the pathophysiologic mechanism explaining this association remains unclear, the recurrence of TTP associated with the "rechallenge" of relapsing episodes of pancreatitis in our patient suggests that a cause-and-effect relationship does exist.

Original languageEnglish (US)
Pages (from-to)1096-1099
Number of pages4
JournalDigestive Diseases and Sciences
Volume47
Issue number5
DOIs
StatePublished - 2002
Externally publishedYes

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Thrombotic Thrombocytopenic Purpura
Pancreatitis
Plasmapheresis
Chronic Pancreatitis
Patient Care
Recurrence

Keywords

  • Acute pancreatitis
  • Plasmapheresis
  • Renal failure
  • Thrombotic thrombocytopenic purpura

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Recurrent thrombotic thrombocytopenic purpura (TTP) as a complication of acute relapsing pancreatitis. / Talwalkar, Jayant A.; Ruymann, Frederick W.; Marcoux, Paul; Farraye, Francis A.

In: Digestive Diseases and Sciences, Vol. 47, No. 5, 2002, p. 1096-1099.

Research output: Contribution to journalArticle

Talwalkar, Jayant A. ; Ruymann, Frederick W. ; Marcoux, Paul ; Farraye, Francis A. / Recurrent thrombotic thrombocytopenic purpura (TTP) as a complication of acute relapsing pancreatitis. In: Digestive Diseases and Sciences. 2002 ; Vol. 47, No. 5. pp. 1096-1099.
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