Recurrent papillary craniopharyngioma with BRAF V600E mutation treated with dabrafenib: Case report

Benjamin T. Himes, Michael W. Ruff, Jamie Van Gompel, Sean S Park, Evanthia Galanis, Timothy J Kaufmann, Joon H. Uhm

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The authors present the case of a man with a papillary craniopharyngioma, first diagnosed at 47 years of age, who experienced multiple recurrences. Review of the pathologic specimen from his first resection demonstrated the BRAF V600E mutation. With his most recent recurrence following previous surgery and radiotherapy, at 52 years of age, the decision was made to initiate treatment with the BRAF V600E inhibitor dabrafenib. Imaging following initiation of dabrafenib demonstrated reduction in tumor size. He remained on dabrafenib therapy for approximately 1 year and continued to demonstrate a good clinical result. At that time the decision was made to discontinue dabrafenib therapy and follow up with serial imaging. After more than 1 year of follow-up since stopping dabrafenib, the patient has continued to do well with no radiographic evidence of tumor progression and continues to be monitored with frequent interval imaging.

Original languageEnglish (US)
Pages (from-to)1299-1303
Number of pages5
JournalJournal of neurosurgery
Volume130
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Craniopharyngioma
Mutation
Recurrence
Neoplasms
Radiotherapy
Therapeutics
dabrafenib

Keywords

  • BRAF V600E
  • Craniopharyngioma
  • Dabrafenib
  • Oncology
  • Papillary

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Recurrent papillary craniopharyngioma with BRAF V600E mutation treated with dabrafenib : Case report. / Himes, Benjamin T.; Ruff, Michael W.; Van Gompel, Jamie; Park, Sean S; Galanis, Evanthia; Kaufmann, Timothy J; Uhm, Joon H.

In: Journal of neurosurgery, Vol. 130, No. 4, 01.04.2019, p. 1299-1303.

Research output: Contribution to journalArticle

@article{7d8ae2f8a225454890343c3313da744f,
title = "Recurrent papillary craniopharyngioma with BRAF V600E mutation treated with dabrafenib: Case report",
abstract = "The authors present the case of a man with a papillary craniopharyngioma, first diagnosed at 47 years of age, who experienced multiple recurrences. Review of the pathologic specimen from his first resection demonstrated the BRAF V600E mutation. With his most recent recurrence following previous surgery and radiotherapy, at 52 years of age, the decision was made to initiate treatment with the BRAF V600E inhibitor dabrafenib. Imaging following initiation of dabrafenib demonstrated reduction in tumor size. He remained on dabrafenib therapy for approximately 1 year and continued to demonstrate a good clinical result. At that time the decision was made to discontinue dabrafenib therapy and follow up with serial imaging. After more than 1 year of follow-up since stopping dabrafenib, the patient has continued to do well with no radiographic evidence of tumor progression and continues to be monitored with frequent interval imaging.",
keywords = "BRAF V600E, Craniopharyngioma, Dabrafenib, Oncology, Papillary",
author = "Himes, {Benjamin T.} and Ruff, {Michael W.} and {Van Gompel}, Jamie and Park, {Sean S} and Evanthia Galanis and Kaufmann, {Timothy J} and Uhm, {Joon H.}",
year = "2019",
month = "4",
day = "1",
doi = "10.3171/2017.11.JNS172373",
language = "English (US)",
volume = "130",
pages = "1299--1303",
journal = "Journal of Neurosurgery",
issn = "0022-3085",
publisher = "American Association of Neurological Surgeons",
number = "4",

}

TY - JOUR

T1 - Recurrent papillary craniopharyngioma with BRAF V600E mutation treated with dabrafenib

T2 - Case report

AU - Himes, Benjamin T.

AU - Ruff, Michael W.

AU - Van Gompel, Jamie

AU - Park, Sean S

AU - Galanis, Evanthia

AU - Kaufmann, Timothy J

AU - Uhm, Joon H.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The authors present the case of a man with a papillary craniopharyngioma, first diagnosed at 47 years of age, who experienced multiple recurrences. Review of the pathologic specimen from his first resection demonstrated the BRAF V600E mutation. With his most recent recurrence following previous surgery and radiotherapy, at 52 years of age, the decision was made to initiate treatment with the BRAF V600E inhibitor dabrafenib. Imaging following initiation of dabrafenib demonstrated reduction in tumor size. He remained on dabrafenib therapy for approximately 1 year and continued to demonstrate a good clinical result. At that time the decision was made to discontinue dabrafenib therapy and follow up with serial imaging. After more than 1 year of follow-up since stopping dabrafenib, the patient has continued to do well with no radiographic evidence of tumor progression and continues to be monitored with frequent interval imaging.

AB - The authors present the case of a man with a papillary craniopharyngioma, first diagnosed at 47 years of age, who experienced multiple recurrences. Review of the pathologic specimen from his first resection demonstrated the BRAF V600E mutation. With his most recent recurrence following previous surgery and radiotherapy, at 52 years of age, the decision was made to initiate treatment with the BRAF V600E inhibitor dabrafenib. Imaging following initiation of dabrafenib demonstrated reduction in tumor size. He remained on dabrafenib therapy for approximately 1 year and continued to demonstrate a good clinical result. At that time the decision was made to discontinue dabrafenib therapy and follow up with serial imaging. After more than 1 year of follow-up since stopping dabrafenib, the patient has continued to do well with no radiographic evidence of tumor progression and continues to be monitored with frequent interval imaging.

KW - BRAF V600E

KW - Craniopharyngioma

KW - Dabrafenib

KW - Oncology

KW - Papillary

UR - http://www.scopus.com/inward/record.url?scp=85052939565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052939565&partnerID=8YFLogxK

U2 - 10.3171/2017.11.JNS172373

DO - 10.3171/2017.11.JNS172373

M3 - Article

AN - SCOPUS:85052939565

VL - 130

SP - 1299

EP - 1303

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - 4

ER -