TY - JOUR
T1 - Recurrent hepatitis C virus after liver transplantation
T2 - The role of quasispecies complexity and diversity
AU - Gallegos-Orozco, Juan F.
AU - Vargas, Hugo E.
PY - 2004
Y1 - 2004
N2 - Quasispecies analyses by different investigators have conflicted with regard to the importance of quasispecies in HCV recurrence after liver transplantation. This is in part because of small sample size, nonuniform time points, differing analysis techniques, and differing definitions of genetic diversity. Because of the great potential for diagnostic and therapeutic use, future study of quasispecies diversity and complexity should be conducted in larger trials with well-defined histologic and clinical outcomes, and protocol-defined liver biopsies and controlled immunosuppressive regimens. This approach will allow better definition of the role of viral quasispecies in the pathogenesis and severity of recurrence of posttransplant hepatitis C infection.
AB - Quasispecies analyses by different investigators have conflicted with regard to the importance of quasispecies in HCV recurrence after liver transplantation. This is in part because of small sample size, nonuniform time points, differing analysis techniques, and differing definitions of genetic diversity. Because of the great potential for diagnostic and therapeutic use, future study of quasispecies diversity and complexity should be conducted in larger trials with well-defined histologic and clinical outcomes, and protocol-defined liver biopsies and controlled immunosuppressive regimens. This approach will allow better definition of the role of viral quasispecies in the pathogenesis and severity of recurrence of posttransplant hepatitis C infection.
KW - Recurrent hepatitis
KW - Transplant virology
KW - Viral quasispecies
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U2 - 10.1097/01.mot.0000127679.62641.52
DO - 10.1097/01.mot.0000127679.62641.52
M3 - Review article
AN - SCOPUS:77950067072
SN - 1087-2418
VL - 9
SP - 99
EP - 103
JO - Current opinion in organ transplantation
JF - Current opinion in organ transplantation
IS - 2
ER -