Recurrent hepatitis C virus after liver transplantation: The role of quasispecies complexity and diversity

Juan F. Gallegos-Orozco, Hugo E. Vargas

Research output: Contribution to journalReview articlepeer-review

Abstract

Quasispecies analyses by different investigators have conflicted with regard to the importance of quasispecies in HCV recurrence after liver transplantation. This is in part because of small sample size, nonuniform time points, differing analysis techniques, and differing definitions of genetic diversity. Because of the great potential for diagnostic and therapeutic use, future study of quasispecies diversity and complexity should be conducted in larger trials with well-defined histologic and clinical outcomes, and protocol-defined liver biopsies and controlled immunosuppressive regimens. This approach will allow better definition of the role of viral quasispecies in the pathogenesis and severity of recurrence of posttransplant hepatitis C infection.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalCurrent opinion in organ transplantation
Volume9
Issue number2
DOIs
StatePublished - Jan 1 2004

Keywords

  • Recurrent hepatitis
  • Transplant virology
  • Viral quasispecies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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