Recurrent goodpasture's disease due to a monoclonal IgA-kappa circulating antibody

F. C. Fervenza, D. Terreros, A. Boutaud, B. G. Hudson, Jr Williams, Jr Donadio, T. R. Schwab

Research output: Contribution to journalArticle

31 Scopus citations


We describe the case of a 54-year-old man who first presented with a clinical syndrome manifested by recurrent pulmonary hemorrhage, hematuria, and mild renal insufficiency. Direct immunofluorescence of renal biopsy sections showed linear deposition of IgA-kappa in the glomerular (GBM) and tubular basement membranes. Serum protein immunoelectrophoresis was positive for a monoclonal immunoglobulin A (IgA)-kappa protein. Serum analysis showed circulating IgA anti-GBM antibodies. Treatment with high-dose steroids, cyclophosphamide, and plasma exchange resulted in resolution of the clinical picture. To the best of our knowledge, this is the first report of Goodpasture's disease associated with the presence of a circulating monoclonal IgA-kappa antibody.

Original languageEnglish (US)
Pages (from-to)549-555
Number of pages7
JournalAmerican Journal of Kidney Diseases
Issue number3
StatePublished - Jan 1 1999


  • Anti-glomerular basement membrane antibody disease
  • Glomerulonephritis
  • Goodpasture's syndrome
  • IgA nephropathy
  • Immunoglobulin A (IgA) monoclonal gammopathy
  • Pulmonary hemorrhage

ASJC Scopus subject areas

  • Nephrology

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