Recurrent goodpasture's disease due to a monoclonal IgA-kappa circulating antibody

F. C. Fervenza; D. Terreros; A. Boutaud; B. G. Hudson; Jr Williams; Jr Donadio; T. R. Schwab

doi:10.1016/S0272-6386(99)70084-3

Recurrent goodpasture's disease due to a monoclonal IgA-kappa circulating antibody

F. C. Fervenza, D. Terreros, A. Boutaud, B. G. Hudson, Jr Williams, Jr Donadio, T. R. Schwab

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We describe the case of a 54-year-old man who first presented with a clinical syndrome manifested by recurrent pulmonary hemorrhage, hematuria, and mild renal insufficiency. Direct immunofluorescence of renal biopsy sections showed linear deposition of IgA-kappa in the glomerular (GBM) and tubular basement membranes. Serum protein immunoelectrophoresis was positive for a monoclonal immunoglobulin A (IgA)-kappa protein. Serum analysis showed circulating IgA anti-GBM antibodies. Treatment with high-dose steroids, cyclophosphamide, and plasma exchange resulted in resolution of the clinical picture. To the best of our knowledge, this is the first report of Goodpasture's disease associated with the presence of a circulating monoclonal IgA-kappa antibody.

Original language	English (US)
Pages (from-to)	549-555
Number of pages	7
Journal	American Journal of Kidney Diseases
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/S0272-6386(99)70084-3
State	Published - 1999

Keywords

Anti-glomerular basement membrane antibody disease
Glomerulonephritis
Goodpasture's syndrome
IgA nephropathy
Immunoglobulin A (IgA) monoclonal gammopathy
Pulmonary hemorrhage

ASJC Scopus subject areas

Nephrology

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10.1016/S0272-6386(99)70084-3

Cite this

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title = "Recurrent goodpasture's disease due to a monoclonal IgA-kappa circulating antibody",

abstract = "We describe the case of a 54-year-old man who first presented with a clinical syndrome manifested by recurrent pulmonary hemorrhage, hematuria, and mild renal insufficiency. Direct immunofluorescence of renal biopsy sections showed linear deposition of IgA-kappa in the glomerular (GBM) and tubular basement membranes. Serum protein immunoelectrophoresis was positive for a monoclonal immunoglobulin A (IgA)-kappa protein. Serum analysis showed circulating IgA anti-GBM antibodies. Treatment with high-dose steroids, cyclophosphamide, and plasma exchange resulted in resolution of the clinical picture. To the best of our knowledge, this is the first report of Goodpasture's disease associated with the presence of a circulating monoclonal IgA-kappa antibody.",

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AU - Fervenza, F. C.

AU - Terreros, D.

AU - Boutaud, A.

AU - Hudson, B. G.

AU - Williams, Jr

AU - Donadio, Jr

AU - Schwab, T. R.

PY - 1999

Y1 - 1999

N2 - We describe the case of a 54-year-old man who first presented with a clinical syndrome manifested by recurrent pulmonary hemorrhage, hematuria, and mild renal insufficiency. Direct immunofluorescence of renal biopsy sections showed linear deposition of IgA-kappa in the glomerular (GBM) and tubular basement membranes. Serum protein immunoelectrophoresis was positive for a monoclonal immunoglobulin A (IgA)-kappa protein. Serum analysis showed circulating IgA anti-GBM antibodies. Treatment with high-dose steroids, cyclophosphamide, and plasma exchange resulted in resolution of the clinical picture. To the best of our knowledge, this is the first report of Goodpasture's disease associated with the presence of a circulating monoclonal IgA-kappa antibody.

AB - We describe the case of a 54-year-old man who first presented with a clinical syndrome manifested by recurrent pulmonary hemorrhage, hematuria, and mild renal insufficiency. Direct immunofluorescence of renal biopsy sections showed linear deposition of IgA-kappa in the glomerular (GBM) and tubular basement membranes. Serum protein immunoelectrophoresis was positive for a monoclonal immunoglobulin A (IgA)-kappa protein. Serum analysis showed circulating IgA anti-GBM antibodies. Treatment with high-dose steroids, cyclophosphamide, and plasma exchange resulted in resolution of the clinical picture. To the best of our knowledge, this is the first report of Goodpasture's disease associated with the presence of a circulating monoclonal IgA-kappa antibody.

KW - Anti-glomerular basement membrane antibody disease

KW - Glomerulonephritis

KW - Goodpasture's syndrome

KW - IgA nephropathy

KW - Immunoglobulin A (IgA) monoclonal gammopathy

KW - Pulmonary hemorrhage

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Recurrent goodpasture's disease due to a monoclonal IgA-kappa circulating antibody

Abstract

Keywords

ASJC Scopus subject areas

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