Recurrent glioblastoma multiforme: Advances in treatment and promising drug candidates

Lijo Simpson; Evanthia Galanis

doi:10.1586/14737140.6.11.1593

Recurrent glioblastoma multiforme: Advances in treatment and promising drug candidates

Lijo Simpson, Evanthia Galanis

Medical Oncology

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Recurrent glioblastoma multiforme is a lethal disease with currently available treatment options having a limited impact on outcome. In this article, current and novel therapeutic approaches in the treatment of recurrent glioblastoma multiforme, including chemotherapy, targeted molecular agents, virotherapy/gene therapy and immunotherapy and challenges in developing novel therapeutic agents for glioblastoma multiforme will be discussed.

Original language	English (US)
Pages (from-to)	1593-1607
Number of pages	15
Journal	Expert review of anticancer therapy
Volume	6
Issue number	11
DOIs	https://doi.org/10.1586/14737140.6.11.1593
State	Published - Nov 2006

Keywords

Chemotherapy
Gene therapy
Glioblastoma multiforme
Immunotherapy
Recurrence
Small molecule cell cycle inhibitors

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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10.1586/14737140.6.11.1593

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title = "Recurrent glioblastoma multiforme: Advances in treatment and promising drug candidates",

abstract = "Recurrent glioblastoma multiforme is a lethal disease with currently available treatment options having a limited impact on outcome. In this article, current and novel therapeutic approaches in the treatment of recurrent glioblastoma multiforme, including chemotherapy, targeted molecular agents, virotherapy/gene therapy and immunotherapy and challenges in developing novel therapeutic agents for glioblastoma multiforme will be discussed.",

keywords = "Chemotherapy, Gene therapy, Glioblastoma multiforme, Immunotherapy, Recurrence, Small molecule cell cycle inhibitors",

author = "Lijo Simpson and Evanthia Galanis",

note = "Funding Information: Supported in part by the National Institutes of Health Grants P50 CA 108961 (EG), R21CA 103276 (EG), and a National Brain Tumor Foundation Grant FNDT-1 (EG).",

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AU - Galanis, Evanthia

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AB - Recurrent glioblastoma multiforme is a lethal disease with currently available treatment options having a limited impact on outcome. In this article, current and novel therapeutic approaches in the treatment of recurrent glioblastoma multiforme, including chemotherapy, targeted molecular agents, virotherapy/gene therapy and immunotherapy and challenges in developing novel therapeutic agents for glioblastoma multiforme will be discussed.

KW - Chemotherapy

KW - Gene therapy

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KW - Immunotherapy

KW - Recurrence

KW - Small molecule cell cycle inhibitors

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Recurrent glioblastoma multiforme: Advances in treatment and promising drug candidates

Abstract

Keywords

ASJC Scopus subject areas

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