Recurrent desmoid-type fibromatosis associated with underlying neuromuscular choristoma

Jonathan J. Stone, Nikhil K. Prasad, Pierre Laumonerie, B. Matthew Howe, Kimberly K. Amrami, Jodi M. Carter, Mark E. Jentoft, Robert Spinner

Research output: Contribution to journalArticle

Abstract

Objective: Desmoid-type fibromatosis (DTF) presents a therapeutic dilemma. While lacking metastatic potential, it is a locally aggressive tumor with a strong propensity for occurrence near nerve(s) and recurrence following resection. In this study, the authors introduce the association of an occult neuromuscular choristoma (NMC) identified in patients with DTF. Methods: After experiencing a case of DTF found to have an occult NMC, the authors performed a retrospective database review of all other cases of biopsy-proven DTF involving the extremities or limb girdles in patients with available MRI data. Two musculoskeletal radiologists with expertise in peripheral nerve imaging reviewed the MRI studies of the eligible cases for evidence of previously unrecognized NMC. Results: The initial case of a patient with an occult sciatic NMC is described. The database review yielded 40 patients with DTF-18 (45%) in the upper limb and 22 (55%) in the lower limb. Two cases (5%) had MRI findings of NMC associated with the DTF, one in the proximal sciatic nerve and the other in the proximal tibial and sural nerves. Conclusions: The coexistence of NMC may be under-recognized in a subset of patients with extremity DTF. This finding poses implications for DTF treatment and the likelihood of recurrence after resection or biopsy. Further study may reveal crucial links between the pathogenesis of NMC and DTF and offer novel therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalJournal of neurosurgery
Volume131
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Aggressive
  • Choristoma
  • Fibromatosis
  • Local
  • Neoplasm recurrence
  • Peripheral nerve
  • Sciatic nerve

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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  • Cite this

    Stone, J. J., Prasad, N. K., Laumonerie, P., Howe, B. M., Amrami, K. K., Carter, J. M., Jentoft, M. E., & Spinner, R. (2019). Recurrent desmoid-type fibromatosis associated with underlying neuromuscular choristoma. Journal of neurosurgery, 131(1), 175-183. https://doi.org/10.3171/2018.3.JNS152935