Recurrence in Bipolar I Disorder: A Post Hoc Analysis Excluding Relapses in Two Double-blind Maintenance Studies

Joseph R. Calabrese, Joseph F. Goldberg, Terence A. Ketter, Trisha Suppes, Mark A Frye, Robin White, Angela DeVeaugh-Geiss, Thomas R. Thompson

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: To assess the efficacy of lamotrigine or lithium in preventing mood recurrence (i.e., a new mood episode) in bipolar disorder. Methods: Data from bipolar I patients with relapses (i.e., mood episodes having the same polarity as the index episode within 90 or 180 days of randomization) were excluded from post hoc efficacy analyses of two 18-month, placebo-controlled maintenance trials of lamotrigine and lithium. Results: Both lamotrigine and lithium were more effective than placebo in delaying the time to intervention for any mood episode (depression, mania, hypomania, or mixed) when relapses that occurred in the first 90 days were excluded from the analyses (p = .002, lamotrigine vs. placebo; p = .010, lithium vs. placebo). Results were similar when patients with mood episodes within 180 days of randomization were excluded. Conclusions: Both lamotrigine and lithium maintenance therapy protected against mood episode recurrence in bipolar I disorder.

Original languageEnglish (US)
Pages (from-to)1061-1064
Number of pages4
JournalBiological Psychiatry
Volume59
Issue number11
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

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Bipolar Disorder
Double-Blind Method
Lithium
Maintenance
Recurrence
Placebos
Random Allocation
lamotrigine
Depression

Keywords

  • Bipolar
  • depression
  • lamotrigine
  • maintenance
  • mania
  • recurrence

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Recurrence in Bipolar I Disorder : A Post Hoc Analysis Excluding Relapses in Two Double-blind Maintenance Studies. / Calabrese, Joseph R.; Goldberg, Joseph F.; Ketter, Terence A.; Suppes, Trisha; Frye, Mark A; White, Robin; DeVeaugh-Geiss, Angela; Thompson, Thomas R.

In: Biological Psychiatry, Vol. 59, No. 11, 01.06.2006, p. 1061-1064.

Research output: Contribution to journalArticle

Calabrese, JR, Goldberg, JF, Ketter, TA, Suppes, T, Frye, MA, White, R, DeVeaugh-Geiss, A & Thompson, TR 2006, 'Recurrence in Bipolar I Disorder: A Post Hoc Analysis Excluding Relapses in Two Double-blind Maintenance Studies', Biological Psychiatry, vol. 59, no. 11, pp. 1061-1064. https://doi.org/10.1016/j.biopsych.2006.02.034
Calabrese, Joseph R. ; Goldberg, Joseph F. ; Ketter, Terence A. ; Suppes, Trisha ; Frye, Mark A ; White, Robin ; DeVeaugh-Geiss, Angela ; Thompson, Thomas R. / Recurrence in Bipolar I Disorder : A Post Hoc Analysis Excluding Relapses in Two Double-blind Maintenance Studies. In: Biological Psychiatry. 2006 ; Vol. 59, No. 11. pp. 1061-1064.
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