@article{31b703b28b4b4f0faf0f318c5377b388,
title = "Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium",
abstract = "Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.",
keywords = "epithelial ovarian cancer, inactivity, mortality risk, recreational physical activity, survival",
author = "Cannioto, {Rikki A.} and LaMonte, {Michael J.} and Kelemen, {Linda E.} and Risch, {Harvey A.} and Eng, {Kevin H.} and Minlikeeva, {Albina N.} and Hong, {Chi Chen} and Szender, {J. Brian} and Lara Sucheston-Campbell and Joseph, {Janine M.} and Andrew Berchuck and Jenny Chang-Claude and Cramer, {Daniel W.} and {De Fazio}, Anna and Brenda Diergaarde and Thilo D{\"o}rk and Doherty, {Jennifer A.} and Edwards, {Robert P.} and Fridley, {Brooke L.} and Grace Friel and Goode, {Ellen L.} and Goodman, {Marc T.} and Peter Hillemanns and Estrid Hogdall and Satoyo Hosono and Kelley, {Joseph L.} and Kjaer, {Susanne K.} and Rudiger Klapdor and Keitaro Matsuo and Kunle Odunsi and Nagle, {Christina M.} and Olsen, {Catherine M.} and Paddock, {Lisa E.} and Pearce, {Celeste L.} and Pike, {Malcolm C.} and Rossing, {Mary A.} and Barbara Schmalfeldt and Segal, {Brahm H.} and Szamreta, {Elizabeth A.} and Thompson, {Pamela J.} and Tseng, {Chiu Chen} and Robert Vierkant and Schildkraut, {Joellen M.} and Nicolas Wentzensen and Wicklund, {Kristine G.} and Winham, {Stacey J.} and Wu, {Anna H.} and Francesmary Modugno and Ness, {Roberta B.} and Allan Jensen and Webb, {Penelope M.} and Kathryn Terry and Bandera, {Elisa V.} and Moysich, {Kirsten B.}",
note = "Funding Information: KBM is supported by NIH/NCI R01CA095023 and NIH/NCI R01CA126841; KHE and KBM were supported by the Roswell Park Alliance Foundation; JBS was supported by 5T32CA108456; ANM was supported by Interdisciplinary Training Grant in Cancer Epidemiology R25CA113951; BHS was supported by R01 CA188900; AUS was supported by the U.S. Army Medical Research and Materiel Command (DAMD17-01-1-0729), National Health & Medical Research Council of Australia, Cancer Councils of New South Wales, Victoria, Queensland, South Australia and Tasmania, Cancer Foundation of Western Australia; National Health and Medical Research Council of Australia (199600 and 400281); CON was supported by National Institutes of Health (R01-CA074850; R01-CA080742); DOV was supported by National Institutes of Health R01-CA112523 and R01-CA87538; HAW was supported by U.S. National Institutes of Health (R01-CA58598, N01-CN-55424 and N01-PC-67001); HOP was supported by DOD: DAMD17-02-1-0669 and NCI: K07-CA080668, R01-CA95023, P50-CA159981, R01-CA126841; JPN was supported by Grant-in-Aid for the Third Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare; MAC was supported by National Institutes of Health (R01-CA122443, P30-CA15083, P50-CA136393); MAL was supported by research grant R01- CA61107 from the National Cancer Institute, Bethesda, MD; research grant 94 222 52 from the Danish Cancer Society, Copenhagen, Denmark; and the Mermaid I project; MAY was supported by National Institutes of Health (R01-CA122443, P30-CA15083, P50-CA136393); Mayo Foundation; Minnesota Ovarian Cancer Alliance; Fred C. and Katherine B. Andersen Foundation; NEC was supported by National Institutes of Health R01-CA54419 and P50-CA105009 and Department of Defense W81XWH-10-1-02802; NJO was supported by National Cancer Institute (NIH-K07 CA095666, R01-CA83918, NIH-K22- CA138563, and P30-CA072720) and the Cancer Institute of New Jersey and NCI CCSG award (P30-CA008748); USC was supported by P01CA17054, P30CA14089, R01CA61132, N01PC67010, R03CA113148, R03CA115195, N01CN025403, and California Cancer Research Program (00-01389V-20170, 2II0200). Publisher Copyright: {\textcopyright} 2016 Cancer Research UK.",
year = "2016",
month = jun,
day = "28",
doi = "10.1038/bjc.2016.153",
language = "English (US)",
volume = "115",
pages = "95--101",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "1",
}