Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: Evidence from the Ovarian Cancer Association Consortium

Rikki A. Cannioto, Michael J. LaMonte, Linda E. Kelemen, Harvey A. Risch, Kevin H. Eng, Albina N. Minlikeeva, Chi Chen Hong, J. Brian Szender, Lara Sucheston-Campbell, Janine M. Joseph, Andrew Berchuck, Jenny Chang-Claude, Daniel W. Cramer, Anna De Fazio, Brenda Diergaarde, Thilo Dörk, Jennifer A. Doherty, Robert P. Edwards, Brooke L. Fridley, Grace FrielEllen L. Goode, Marc T. Goodman, Peter Hillemanns, Estrid Hogdall, Satoyo Hosono, Joseph L. Kelley, Susanne K. Kjaer, Rudiger Klapdor, Keitaro Matsuo, Kunle Odunsi, Christina M. Nagle, Catherine M. Olsen, Lisa E. Paddock, Celeste L. Pearce, Malcolm C. Pike, Mary A. Rossing, Barbara Schmalfeldt, Brahm H. Segal, Elizabeth A. Szamreta, Pamela J. Thompson, Chiu Chen Tseng, Robert Vierkant, Joellen M. Schildkraut, Nicolas Wentzensen, Kristine G. Wicklund, Stacey J. Winham, Anna H. Wu, Francesmary Modugno, Roberta B. Ness, Allan Jensen, Penelope M. Webb, Kathryn Terry, Elisa V. Bandera, Kirsten B. Moysich

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalBritish journal of cancer
Issue number1
StatePublished - Jun 28 2016


  • epithelial ovarian cancer
  • inactivity
  • mortality risk
  • recreational physical activity
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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