Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis

W. Ian McDonald, Alistair Compston, Gilles Edan, Donald Goodkin, Hans Peter Hartung, Fred D. Lublin, Henry F. McFarland, Donald W. Paty, Chris H. Polman, Stephen C. Reingold, Magnhild Sandberg-Wollheim, William Sibley, Alan Thompson, Stanley Van Den Noort, Brian Y. Weinshenker, Jerry S. Wolinsky

Research output: Contribution to journalArticle

5425 Scopus citations

Abstract

The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with clinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without dear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS".

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalAnnals of neurology
Volume50
Issue number1
DOIs
StatePublished - Jul 10 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H. P., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., Sandberg-Wollheim, M., Sibley, W., Thompson, A., Van Den Noort, S., Weinshenker, B. Y., & Wolinsky, J. S. (2001). Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Annals of neurology, 50(1), 121-127. https://doi.org/10.1002/ana.1032