Recognition of genetic syndromes in families with suspected hereditary colon cancer syndromes

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

There is an increasing number of genetic disorders that predispose to colorectal cancer. Although these syndromes probably account for <5% of colorectal cancers, clinical recognition of these disorders is essential to assure the best clinical recommendations. There are increased risks for second cancers - both GI and non-GI cancers - in the patients and their relatives. Diagnosis of a familial cancer predisposition syndrome guides clinical management including early detection and prevention of cancers in such families.

Original languageEnglish (US)
Pages (from-to)366-375
Number of pages10
JournalClinical Gastroenterology and Hepatology
Volume2
Issue number5
DOIs
StatePublished - May 2004

Fingerprint

Hereditary Neoplastic Syndromes
Colonic Neoplasms
Colorectal Neoplasms
Inborn Genetic Diseases
Second Primary Neoplasms
Early Detection of Cancer
Neoplasms

Keywords

  • gastrointestinal
  • GI
  • hereditary nonpolyposis colon cancer
  • HNPCC
  • IHC
  • immunohistochemistry
  • microsatellite instability
  • MSI

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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abstract = "There is an increasing number of genetic disorders that predispose to colorectal cancer. Although these syndromes probably account for <5{\%} of colorectal cancers, clinical recognition of these disorders is essential to assure the best clinical recommendations. There are increased risks for second cancers - both GI and non-GI cancers - in the patients and their relatives. Diagnosis of a familial cancer predisposition syndrome guides clinical management including early detection and prevention of cancers in such families.",
keywords = "gastrointestinal, GI, hereditary nonpolyposis colon cancer, HNPCC, IHC, immunohistochemistry, microsatellite instability, MSI",
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AB - There is an increasing number of genetic disorders that predispose to colorectal cancer. Although these syndromes probably account for <5% of colorectal cancers, clinical recognition of these disorders is essential to assure the best clinical recommendations. There are increased risks for second cancers - both GI and non-GI cancers - in the patients and their relatives. Diagnosis of a familial cancer predisposition syndrome guides clinical management including early detection and prevention of cancers in such families.

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KW - hereditary nonpolyposis colon cancer

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KW - IHC

KW - immunohistochemistry

KW - microsatellite instability

KW - MSI

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