TY - JOUR
T1 - Receptor pharmacology of neuroleptics
T2 - Relation to clinical effects
AU - Richelson, Elliott
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - This article reviews the receptor pharmacology of neuroleptics, with a focus on newer drugs (e.g., risperidone, olanzapine, sertindole, quetiapine, and ziprasidone) in contrast to older compounds. All these newer compounds are considered to be atypical neuroleptics based upon certain criteria, which are reviewed. Several hypotheses about the molecular mechanisms that explain atypicality are considered. Finally, the in vitro receptor binding data presented for these compounds are related to the therapeutic and adverse effects of these drugs.
AB - This article reviews the receptor pharmacology of neuroleptics, with a focus on newer drugs (e.g., risperidone, olanzapine, sertindole, quetiapine, and ziprasidone) in contrast to older compounds. All these newer compounds are considered to be atypical neuroleptics based upon certain criteria, which are reviewed. Several hypotheses about the molecular mechanisms that explain atypicality are considered. Finally, the in vitro receptor binding data presented for these compounds are related to the therapeutic and adverse effects of these drugs.
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M3 - Article
C2 - 10340682
AN - SCOPUS:0032935962
SN - 0160-6689
VL - 60
SP - 5
EP - 14
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
IS - SUPPL. 10
ER -