Receptor pharmacology of neuroleptics: Relation to clinical effects

Elliott Richelson

Research output: Contribution to journalArticle

298 Scopus citations


This article reviews the receptor pharmacology of neuroleptics, with a focus on newer drugs (e.g., risperidone, olanzapine, sertindole, quetiapine, and ziprasidone) in contrast to older compounds. All these newer compounds are considered to be atypical neuroleptics based upon certain criteria, which are reviewed. Several hypotheses about the molecular mechanisms that explain atypicality are considered. Finally, the in vitro receptor binding data presented for these compounds are related to the therapeutic and adverse effects of these drugs.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 10
StatePublished - May 31 1999

ASJC Scopus subject areas

  • Psychiatry and Mental health

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