Recent neuroendocrine facets of male reproductive aging

J. D. Veldhuis

doi:10.1016/S0531-5565(00)00123-6

Recent neuroendocrine facets of male reproductive aging

J. D. Veldhuis

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We recently identified consistent attenuation of LH and testosterone secretory pulse amplitude and associated disruption of their orderly patterns of release in healthy older men. These dynamic changes emerge despite young-adult concentrations of LH and total testosterone. Moreover, we could document disruption of synchrony between LH secretion and oscillations in FSH, prolactin, sleep-stage and NPT (nocturnal penile tumescence), thus pointing to loss of coordinate neurohormone outflow. Such data suggest that CNS-hypothalamically based regulatory defects may be important in aging, as inferred indirectly in the old male rat and mouse more than 15 years ago. How such alterations are related to specific hypothalamic neurotransmitter changes in aging will be critical to unravel. (C) 2000 Elsevier Science Inc.

Original language	English (US)
Pages (from-to)	1281-1308
Number of pages	28
Journal	Experimental Gerontology
Volume	35
Issue number	9-10
DOIs	https://doi.org/10.1016/S0531-5565(00)00123-6
State	Published - 2000

Keywords

Aging
Gonadotropin
Hypogonadism
Luteinizing hormone
Male
Pituitary
Testis

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/S0531-5565(00)00123-6

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title = "Recent neuroendocrine facets of male reproductive aging",

abstract = "We recently identified consistent attenuation of LH and testosterone secretory pulse amplitude and associated disruption of their orderly patterns of release in healthy older men. These dynamic changes emerge despite young-adult concentrations of LH and total testosterone. Moreover, we could document disruption of synchrony between LH secretion and oscillations in FSH, prolactin, sleep-stage and NPT (nocturnal penile tumescence), thus pointing to loss of coordinate neurohormone outflow. Such data suggest that CNS-hypothalamically based regulatory defects may be important in aging, as inferred indirectly in the old male rat and mouse more than 15 years ago. How such alterations are related to specific hypothalamic neurotransmitter changes in aging will be critical to unravel. (C) 2000 Elsevier Science Inc.",

keywords = "Aging, Gonadotropin, Hypogonadism, Luteinizing hormone, Male, Pituitary, Testis",

author = "Veldhuis, {J. D.}",

note = "Funding Information: We thank Patsy Craig for her skillful preparation of the manuscript; Paula P. Azimi for the deconvolution analysis, data management, and graphics; Brenda Grisso and Ginger Bauler for performance of the immunoassays; and Sandra Jackson and the expert nursing staff at the University of Virginia General Clinical Research Center for conduct of the research protocols. This work was supported in part by NIH Grant MO1 RR00847 to the General Clinical Research Center of the University of Virginia Health Sciences Center, NIH RO1 AG14799 and NICHD/NIH through cooperative agreement [U-54 HD28934] as part of the Specialized Cooperative Centers Program in Reproduction Research. This focused review necessarily omits many primary references because of editorial constraints. The authors therefore acknowledge numerous colleagues, who have made earlier foundational observations. Kiely, 1999 ",

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KW - Aging

KW - Gonadotropin

KW - Hypogonadism

KW - Luteinizing hormone

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KW - Pituitary

KW - Testis

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Recent neuroendocrine facets of male reproductive aging

Abstract

Keywords

ASJC Scopus subject areas

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