Recent neuroendocrine facets of male reproductive aging

Johannes D Veldhuis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We recently identified consistent attenuation of LH and testosterone secretory pulse amplitude and associated disruption of their orderly patterns of release in healthy older men. These dynamic changes emerge despite young-adult concentrations of LH and total testosterone. Moreover, we could document disruption of synchrony between LH secretion and oscillations in FSH, prolactin, sleep-stage and NPT (nocturnal penile tumescence), thus pointing to loss of coordinate neurohormone outflow. Such data suggest that CNS-hypothalamically based regulatory defects may be important in aging, as inferred indirectly in the old male rat and mouse more than 15 years ago. How such alterations are related to specific hypothalamic neurotransmitter changes in aging will be critical to unravel. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)1281-1308
Number of pages28
JournalExperimental Gerontology
Volume35
Issue number9-10
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Neurotransmitter Agents
Testosterone
Aging of materials
Penile Erection
Sleep Stages
Prolactin
Rats
Young Adult
Defects
Sleep

Keywords

  • Aging
  • Gonadotropin
  • Hypogonadism
  • Luteinizing hormone
  • Male
  • Pituitary
  • Testis

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

Cite this

Recent neuroendocrine facets of male reproductive aging. / Veldhuis, Johannes D.

In: Experimental Gerontology, Vol. 35, No. 9-10, 2000, p. 1281-1308.

Research output: Contribution to journalArticle

Veldhuis, Johannes D. / Recent neuroendocrine facets of male reproductive aging. In: Experimental Gerontology. 2000 ; Vol. 35, No. 9-10. pp. 1281-1308.
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