Recent insights into the molecular genetics of dementia

Rosa Rademakers, Anne Rovelet-Lecrux

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Our understanding of the molecular genetic basis of two common neurodegenerative dementias, Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), has greatly advanced in recent years. Progranulin mutations were identified as a major cause of FTLD and a potential susceptibility factor for other forms of dementia. In addition, through copy-number analyses of previously identified disease genes and the study of microRNA regulation in dementia, new evidence emerged to support the view that subtle variability in the expression of known disease proteins could increase the risk for sporadic forms of dementia. Finally, in late-onset AD populations, the first genome-wide association studies were performed and novel potential AD susceptibility genes reported. These exciting findings provide novel insights into the disease mechanisms underlying dementia and hold promise for the development of potential treatments.

Original languageEnglish (US)
Pages (from-to)451-461
Number of pages11
JournalTrends in neurosciences
Volume32
Issue number8
DOIs
StatePublished - Aug 1 2009

ASJC Scopus subject areas

  • Neuroscience(all)

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