Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma

Cheryl R. Hann; Michael P. Fautsch

doi:10.1007/s40135-015-0072-x

Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma

Cheryl R. Hann, Michael P. Fautsch

Ophthalmology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Primary open-angle glaucoma (POAG) is the second leading cause of blindness in the world’s rapidly aging population. POAG is characterized by progressive degeneration of neural structures in the posterior segment, often associated with a concomitant elevation of intraocular pressure (IOP). Changes in IOP are believed to be caused by a disruption in the normal outflow of aqueous humor (AH). This article reviews recent research associated with normal and POAG AH outflow. Novel findings elucidating biochemical and pathological changes in the ocular tissues affected in POAG are presented. Stem cell research, identification of lymphatic markers, and increased use of mouse models give researchers exciting new tools to understand AH outflow, changes associated with POAG, and identify underlying causes of the disease.

Original language	English (US)
Pages (from-to)	67-73
Number of pages	7
Journal	Current Ophthalmology Reports
Volume	3
Issue number	2
DOIs	https://doi.org/10.1007/s40135-015-0072-x
State	Published - Jun 1 2015

Keywords

Anterior segment
Aqueous outflow
Primary open-angle glaucoma (POAG)
Trabecular meshwork

ASJC Scopus subject areas

Ophthalmology

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10.1007/s40135-015-0072-x

Cite this

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title = "Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma",

abstract = "Primary open-angle glaucoma (POAG) is the second leading cause of blindness in the world{\textquoteright}s rapidly aging population. POAG is characterized by progressive degeneration of neural structures in the posterior segment, often associated with a concomitant elevation of intraocular pressure (IOP). Changes in IOP are believed to be caused by a disruption in the normal outflow of aqueous humor (AH). This article reviews recent research associated with normal and POAG AH outflow. Novel findings elucidating biochemical and pathological changes in the ocular tissues affected in POAG are presented. Stem cell research, identification of lymphatic markers, and increased use of mouse models give researchers exciting new tools to understand AH outflow, changes associated with POAG, and identify underlying causes of the disease.",

keywords = "Anterior segment, Aqueous outflow, Primary open-angle glaucoma (POAG), Trabecular meshwork",

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AU - Hann, Cheryl R.

AU - Fautsch, Michael P.

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AB - Primary open-angle glaucoma (POAG) is the second leading cause of blindness in the world’s rapidly aging population. POAG is characterized by progressive degeneration of neural structures in the posterior segment, often associated with a concomitant elevation of intraocular pressure (IOP). Changes in IOP are believed to be caused by a disruption in the normal outflow of aqueous humor (AH). This article reviews recent research associated with normal and POAG AH outflow. Novel findings elucidating biochemical and pathological changes in the ocular tissues affected in POAG are presented. Stem cell research, identification of lymphatic markers, and increased use of mouse models give researchers exciting new tools to understand AH outflow, changes associated with POAG, and identify underlying causes of the disease.

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Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma

Abstract

Keywords

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