Recent advances in understanding/managing eosinophilic esophagitis in adults

Research output: Contribution to journalArticle

Abstract

It is an exciting time for research in eosinophilic esophagitis (EoE). As a new and increasingly prevalent disease, it is receiving considerable attention in the medical world, resulting in a flood of new insights. Clearly, a genetic predisposition seems likely with the identification of abnormalities in thymic stromal lymphopoietin (TSLP), calpain14, and eotaxin-3 genes. There are also well-defined abnormalities described in esophageal epithelial barrier function in these patients. The relationship between gastroesophageal reflux disease (GERD) and EoE remains unclear, but emerging data suggest that the concept of proton pump inhibitor responsive esophageal eosinophilia (PPIREE) may retain less importance, as this subset of patients becomes a likely subset of EoE in general. Finally, we approach the looming issue of long-term maintenance therapy. Although we lack adequate specific data on how to provide long-term pharmacologic treatment, studies clearly show that for most patients, this is a progressive disease that warrants such consideration.

Original languageEnglish (US)
Article number592
JournalF1000Research
Volume4
DOIs
StatePublished - Aug 20 2015

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Eosinophilic Esophagitis
Peptic Esophagitis
Proton Pump Inhibitors
Eosinophilia
Genetic Predisposition to Disease
Gastroesophageal Reflux
Genes
Therapeutics
Research

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Recent advances in understanding/managing eosinophilic esophagitis in adults. / Katzka, David A.

In: F1000Research, Vol. 4, 592, 20.08.2015.

Research output: Contribution to journalArticle

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