Abstract
The hormone leptin plays a critical role in energy homeostasis, although our overall understanding of acutely changing leptin levels still needs improvement. Several developments allow a fresh look at recent and early data on leptin action. This review highlights select recent publications that are relevant for understanding the role played by dynamic changes in circulating leptin levels. We further discuss the relevance for our current understanding of leptin signaling in central neuronal feeding and energy expenditure circuits and highlight cohesive and discrepant findings that need to be addressed in future studies to understand how leptin couples with physiological adaptations of food intake and energy expenditure.
Original language | English (US) |
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Article number | 451 |
Journal | F1000Research |
Volume | 9 |
DOIs | |
State | Published - 2020 |
Keywords
- AgRP
- Arcuate nucleus
- Dorsomedial hypothalamus
- Energy expenditure
- Fiber photometry
- Food intake
- MC4R
- Neuronal activity
- POMC
ASJC Scopus subject areas
- General Immunology and Microbiology
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology