Recent advances in understanding the role of leptin in energy homeostasis

Heike Münzberg, Prachi Singh, Steven B. Heymsfield, Sangho Yu, Christopher D. Morrison

Research output: Contribution to journalReview articlepeer-review

Abstract

The hormone leptin plays a critical role in energy homeostasis, although our overall understanding of acutely changing leptin levels still needs improvement. Several developments allow a fresh look at recent and early data on leptin action. This review highlights select recent publications that are relevant for understanding the role played by dynamic changes in circulating leptin levels. We further discuss the relevance for our current understanding of leptin signaling in central neuronal feeding and energy expenditure circuits and highlight cohesive and discrepant findings that need to be addressed in future studies to understand how leptin couples with physiological adaptations of food intake and energy expenditure.

Original languageEnglish (US)
Article number451
JournalF1000Research
Volume9
DOIs
StatePublished - 2020

Keywords

  • AgRP
  • Arcuate nucleus
  • Dorsomedial hypothalamus
  • Energy expenditure
  • Fiber photometry
  • Food intake
  • MC4R
  • Neuronal activity
  • POMC

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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