TY - JOUR
T1 - Recent advances in understanding and treating vasculitis [version 1; referees
T2 - 2 approved]
AU - Koster, Matthew J.
AU - Warrington, Kenneth J.
N1 - Publisher Copyright:
© 2016 Koster MJ and Warrington KJ.
PY - 2016
Y1 - 2016
N2 - Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are near universally fatal conditions if untreated. Although effective therapeutic options are available for these diseases, treatment regimens are associated with both short- and long-term adverse effects. The recent identification of effective B-cell-targeted therapy with an anti-CD20 monoclonal antibody has transformed the treatment landscape of AAV. Questions, nevertheless, remain regarding the appropriate timing, dose, frequency, duration, and long-term effects of treatment. The aim of this article is to provide an overview of the current information, recent advances, ongoing clinical trials, and future treatment possibilities in AAV.
AB - Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are near universally fatal conditions if untreated. Although effective therapeutic options are available for these diseases, treatment regimens are associated with both short- and long-term adverse effects. The recent identification of effective B-cell-targeted therapy with an anti-CD20 monoclonal antibody has transformed the treatment landscape of AAV. Questions, nevertheless, remain regarding the appropriate timing, dose, frequency, duration, and long-term effects of treatment. The aim of this article is to provide an overview of the current information, recent advances, ongoing clinical trials, and future treatment possibilities in AAV.
UR - http://www.scopus.com/inward/record.url?scp=85010991079&partnerID=8YFLogxK
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U2 - 10.12688/F1000RESEARCH.8403.1
DO - 10.12688/F1000RESEARCH.8403.1
M3 - Review article
AN - SCOPUS:85010991079
VL - 5
JO - F1000Research
JF - F1000Research
SN - 2046-1402
M1 - 1436
ER -