Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms

Tariq I. Mughal; Jason Gotlib; Ruben Mesa; Steffen Koschmieder; H. Jean Khoury; Jorge E. Cortes; Tiziano Barbui; Rüdiger Hehlmann; Michael Mauro; Susanne Saussele; Jerald P. Radich; Richard A. Van Etten; Giuseppe Saglio; Srdnan Verstovek; Robert Peter Gale; Omar Abdel-Wahab

doi:10.1016/j.leukres.2018.02.008

Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms

Tariq I. Mughal, Jason Gotlib, Ruben Mesa, Steffen Koschmieder, H. Jean Khoury, Jorge E. Cortes, Tiziano Barbui, Rüdiger Hehlmann, Michael Mauro, Susanne Saussele, Jerald P. Radich, Richard A. Van Etten, Giuseppe Saglio, Srdnan Verstovek, Robert Peter Gale, Omar Abdel-Wahab

Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

This review is based on the presentations and deliberations at the 7th John Goldman Chronic Myeloid Leukemia (CML) and Myeloproliferative Neoplasms (MPN) Colloquium which took place in Estoril, Portugal on the 15th October 2017, and the 11th post-ASH International Workshop on CML and MPN which took place on the 6th-7th December 2016, immediately after the 58th American Society of Hematology Annual Meeting. Rather than present a resume of the proceedings, we have elected to address some of the topical translational research and clinically relevant topics in greater detail. We address recent updates in the genetics and epigenetics of MPN, the mechanisms of transformation by mutant calreticulin, advances in the biology and therapy of systemic mastocytosis, clinical updates on JAK2 inhibitors and other therapeutic approaches for patients with MPNs, cardiovascular toxicity related to tyrosine kinase inhibitors and the concept of treatment-free remission for patients with CML.

Original language	English (US)
Pages (from-to)	67-74
Number of pages	8
Journal	Leukemia Research
Volume	67
DOIs	https://doi.org/10.1016/j.leukres.2018.02.008
State	Published - Apr 2018

Keywords

CALR
CML
Cardiotoxicity
JAK2 inhibitors
MPN
Mastocytosis
TFR

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2018.02.008

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Mughal, T. I., Gotlib, J., Mesa, R., Koschmieder, S., Khoury, H. J., Cortes, J. E., Barbui, T., Hehlmann, R., Mauro, M., Saussele, S., Radich, J. P., Van Etten, R. A., Saglio, G., Verstovek, S., Gale, R. P., & Abdel-Wahab, O. (2018). Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms. Leukemia Research, 67, 67-74. https://doi.org/10.1016/j.leukres.2018.02.008

Mughal, TI, Gotlib, J, Mesa, R, Koschmieder, S, Khoury, HJ, Cortes, JE, Barbui, T, Hehlmann, R, Mauro, M, Saussele, S, Radich, JP, Van Etten, RA, Saglio, G, Verstovek, S, Gale, RP & Abdel-Wahab, O 2018, 'Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms', Leukemia Research, vol. 67, pp. 67-74. https://doi.org/10.1016/j.leukres.2018.02.008

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abstract = "This review is based on the presentations and deliberations at the 7th John Goldman Chronic Myeloid Leukemia (CML) and Myeloproliferative Neoplasms (MPN) Colloquium which took place in Estoril, Portugal on the 15th October 2017, and the 11th post-ASH International Workshop on CML and MPN which took place on the 6th-7th December 2016, immediately after the 58th American Society of Hematology Annual Meeting. Rather than present a resume of the proceedings, we have elected to address some of the topical translational research and clinically relevant topics in greater detail. We address recent updates in the genetics and epigenetics of MPN, the mechanisms of transformation by mutant calreticulin, advances in the biology and therapy of systemic mastocytosis, clinical updates on JAK2 inhibitors and other therapeutic approaches for patients with MPNs, cardiovascular toxicity related to tyrosine kinase inhibitors and the concept of treatment-free remission for patients with CML.",

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doi = "10.1016/j.leukres.2018.02.008",

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AU - Mughal, Tariq I.

AU - Gotlib, Jason

AU - Mesa, Ruben

AU - Koschmieder, Steffen

AU - Khoury, H. Jean

AU - Cortes, Jorge E.

AU - Barbui, Tiziano

AU - Hehlmann, Rüdiger

AU - Mauro, Michael

AU - Saussele, Susanne

AU - Radich, Jerald P.

AU - Van Etten, Richard A.

AU - Saglio, Giuseppe

AU - Verstovek, Srdnan

AU - Gale, Robert Peter

AU - Abdel-Wahab, Omar

PY - 2018/4

Y1 - 2018/4

N2 - This review is based on the presentations and deliberations at the 7th John Goldman Chronic Myeloid Leukemia (CML) and Myeloproliferative Neoplasms (MPN) Colloquium which took place in Estoril, Portugal on the 15th October 2017, and the 11th post-ASH International Workshop on CML and MPN which took place on the 6th-7th December 2016, immediately after the 58th American Society of Hematology Annual Meeting. Rather than present a resume of the proceedings, we have elected to address some of the topical translational research and clinically relevant topics in greater detail. We address recent updates in the genetics and epigenetics of MPN, the mechanisms of transformation by mutant calreticulin, advances in the biology and therapy of systemic mastocytosis, clinical updates on JAK2 inhibitors and other therapeutic approaches for patients with MPNs, cardiovascular toxicity related to tyrosine kinase inhibitors and the concept of treatment-free remission for patients with CML.

AB - This review is based on the presentations and deliberations at the 7th John Goldman Chronic Myeloid Leukemia (CML) and Myeloproliferative Neoplasms (MPN) Colloquium which took place in Estoril, Portugal on the 15th October 2017, and the 11th post-ASH International Workshop on CML and MPN which took place on the 6th-7th December 2016, immediately after the 58th American Society of Hematology Annual Meeting. Rather than present a resume of the proceedings, we have elected to address some of the topical translational research and clinically relevant topics in greater detail. We address recent updates in the genetics and epigenetics of MPN, the mechanisms of transformation by mutant calreticulin, advances in the biology and therapy of systemic mastocytosis, clinical updates on JAK2 inhibitors and other therapeutic approaches for patients with MPNs, cardiovascular toxicity related to tyrosine kinase inhibitors and the concept of treatment-free remission for patients with CML.

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KW - TFR

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Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms

Abstract

Keywords

ASJC Scopus subject areas

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