Recent advances in experimental modeling of the assembly of tau filaments

Li Wen Ko, Michael DeTure, Naruhiko Sahara, Rifki Chihab, Irving E. Vega, Shu Hui Yen

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Intracellular assembly of microtubule-associated protein tau into filamentous inclusions is central to Alzheimer's disease and related disorders collectively known as tauopathies. Although tau mutations, posttranslational modifications and degradations have been the focus of investigations, the mechanism of tau fibrillogenesis in vivo still remains elusive. Different strategies have been undertaken to generate animal and cellular models for tauopathies. Some are used to study the molecular events leading to the assembly and accumulation of tau filaments, and others to identify potential therapeutic agents that are capable of impeding tauopathy. This review highlights the latest developments in new models and how their utility improves our understanding of the sequence of events leading to human tauopathy.

Original languageEnglish (US)
Pages (from-to)125-139
Number of pages15
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1739
Issue number2
DOIs
StatePublished - Jan 3 2005

Keywords

  • Cellular model
  • Conditional transfectant
  • Tau aggregation
  • Tauopathy

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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