Recent advances in Cys-loop receptor structure and function

Research output: Contribution to journalArticle

384 Citations (Scopus)

Abstract

Throughout the nervous system, moment-to-moment communication relies on postsynaptic receptors to detect neurotransmitters and change the membrane potential. For the Cys-loop superfamily of receptors, recent structural data have catalysed a leap in our understanding of the three steps of chemical-to-electrical transduction: neurotransmitter binding, communication between the binding site and the barrier to ions, and opening and closing of the barrier. The emerging insights might be expected to explain how mutations of receptors cause neurological disease, but the opposite is generally true. Namely, analyses of disease-causing mutations have clarified receptor structure-function relationships as well as mechanisms governing the postsynaptic response.

Original languageEnglish (US)
Pages (from-to)448-455
Number of pages8
JournalNature
Volume440
Issue number7083
DOIs
StatePublished - Mar 23 2006

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Cysteine Loop Ligand-Gated Ion Channel Receptors
Neurotransmitter Agents
Mutation
Membrane Potentials
Nervous System
Binding Sites
Ions

ASJC Scopus subject areas

  • General

Cite this

Recent advances in Cys-loop receptor structure and function. / Sine, Steven M; Engel, Andrew G.

In: Nature, Vol. 440, No. 7083, 23.03.2006, p. 448-455.

Research output: Contribution to journalArticle

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