Reassessment of breakpoints in chromosome 11p15

G. Henry, V. van Heyningen, A. Puech, H. Scrable, P. Augereau, T. Boehm, T. Rabbitts, M. Mannens, H. Rochefort, C. Jones, W. Cavenee, C. Junien

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Specific tumor-associated rearrangements involving the regions 11 p 13 and 11 p 15 have been extensively documented. However, cytogenetic definition of the breakpoints occurring at the boundaries of these two regions was not precise enough to correlate with the molecular data. Using probes corresponding to the genes coding for MYOD1, CTSD, LDHA, and RBTNI and to the anonymous sequence D11S776, we have reassessed the breakpoints of three hybrids (J1.10, BID7, and N YX3.1) and confirmed the localization or more precisely mapped these four genes and the anonymous DNA marker on different subregions of 11 pter→p13, including the smallest region of 11p15.5 duplicated in a patient with Beckwith-Wiedemann syndrome.

Original languageEnglish (US)
Pages (from-to)52-53
Number of pages2
JournalCytogenetic and Genome Research
Volume62
Issue number1
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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