Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.

Original languageEnglish (US)
Pages (from-to)re3
JournalScience's STKE : signal transduction knowledge environment
Volume2006
Issue number332
DOIs
StatePublished - Apr 25 2006

ASJC Scopus subject areas

  • Medicine(all)

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