Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.

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Abstract

Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.

Original languageEnglish (US)
JournalScience's STKE : signal transduction knowledge environment
Volume2006
Issue number332
DOIs
StatePublished - Apr 25 2006

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Mitochondria
Reactive Oxygen Species
Antioxidants
Aging of materials
Proteins

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title = "Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.",
abstract = "Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.",
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