Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.
|Original language||English (US)|
|Journal||Science's STKE : signal transduction knowledge environment|
|State||Published - Apr 25 2006|
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