TY - JOUR
T1 - Reactive oxygen species-mediated mitochondria-to-nucleus signaling
T2 - a key to aging and radical-caused diseases.
AU - Storz, Peter
PY - 2006/4/25
Y1 - 2006/4/25
N2 - Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.
AB - Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.
UR - http://www.scopus.com/inward/record.url?scp=33745500883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745500883&partnerID=8YFLogxK
U2 - 10.1126/stke.3322006re3
DO - 10.1126/stke.3322006re3
M3 - Review article
C2 - 16639035
AN - SCOPUS:33745500883
VL - 2006
SP - re3
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
SN - 1937-9145
IS - 332
ER -