Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.

Peter Storz

doi:10.1126/stke.3322006re3

Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases.

Peter Storz

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

Abstract

Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.

Original language	English (US)
Pages (from-to)	re3
Journal	Science's STKE : signal transduction knowledge environment
Volume	2006
Issue number	332
DOIs	https://doi.org/10.1126/stke.3322006re3
State	Published - Apr 25 2006

ASJC Scopus subject areas

Medicine(all)

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abstract = "Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.",

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