TY - JOUR
T1 - Reactive oxygen species in cancer
AU - Liou, Geou Yarh
AU - Storz, Peter
N1 - Funding Information:
ratory is supported by grants from the Mayo Clinic SPORE for Pancreatic Cancer (P50 CA102701), the Mayo Clinic Breast Cancer SPORE (CA116201-03DR4), an AACR-PANCAN Career development grant (08-20-25-STOR), a R21 from the NCI (CA135102) as well as a Bankhead-Coley grant (FLA07BN-08) from the Florida Department of Health. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the review.
PY - 2010
Y1 - 2010
N2 - Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumour development and progression. However, tumour cells also express increased levels of antioxidant proteins to detoxify from ROS, suggesting that a delicate balance of intracellular ROS levels is required for cancer cell function. Further, the radical generated, the location of its generation, as well as the local concentration is important for the cellular functions of ROS in cancer. A challenge for novel therapeutic strategies will be the fi ne tuning of intracellular ROS signalling to effectively deprive cells from ROS-induced tumour promoting events, towards tipping the balance to ROS-induced apoptotic signalling. Alternatively, therapeutic antioxidants may prevent early events in tumour development, where ROS are important. However, to effectively target cancer cells specifi c ROS-sensing signalling pathways that mediate the diverse stress-regulated cellular functions need to be identifi ed. This review discusses the generation of ROS within tumour cells, their detoxifi cation, their cellular effects, as well as the major signalling cascades they utilize, but also provides an outlook on their modulation in therapeutics.
AB - Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumour development and progression. However, tumour cells also express increased levels of antioxidant proteins to detoxify from ROS, suggesting that a delicate balance of intracellular ROS levels is required for cancer cell function. Further, the radical generated, the location of its generation, as well as the local concentration is important for the cellular functions of ROS in cancer. A challenge for novel therapeutic strategies will be the fi ne tuning of intracellular ROS signalling to effectively deprive cells from ROS-induced tumour promoting events, towards tipping the balance to ROS-induced apoptotic signalling. Alternatively, therapeutic antioxidants may prevent early events in tumour development, where ROS are important. However, to effectively target cancer cells specifi c ROS-sensing signalling pathways that mediate the diverse stress-regulated cellular functions need to be identifi ed. This review discusses the generation of ROS within tumour cells, their detoxifi cation, their cellular effects, as well as the major signalling cascades they utilize, but also provides an outlook on their modulation in therapeutics.
KW - Cancer
KW - Oxidative stress
KW - Reactive oxygen species
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=77951279075&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951279075&partnerID=8YFLogxK
U2 - 10.3109/10715761003667554
DO - 10.3109/10715761003667554
M3 - Review article
C2 - 20370557
AN - SCOPUS:77951279075
SN - 1071-5762
VL - 44
SP - 479
EP - 496
JO - Free Radical Research
JF - Free Radical Research
IS - 5
ER -