Reaction kinetics in intracellular environments: The two proposed models yield qualitatively different predictions

Željko Bajzer, Miljenko Huzak, Kevin Neff, Franklyn G. Prendergast

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

A recently proposed model by Schnell and Turner for reaction kinetics in environments crowded by macromolecules is applied to elementary bimolecular binding. It is found that it leads to an unusual equilibrium constant equal to zero. The progress curves are qualitatively different from the prediction of a model based on a non-integer (fractal) power law proposed earlier by Savageau. In the case of the Michaelis-Menten reaction, the two models predict qualitatively similar progress curves and identical equilibrium concentrations. The two models are investigated analytically and numerically, and their differences are discussed in regard to possible validation of the models by use of experimental data.

Original languageEnglish (US)
Pages (from-to)437-444
Number of pages8
JournalCroatica Chemica Acta
Volume79
Issue number3
StatePublished - Dec 1 2006

Keywords

  • Enzymatic reactions
  • Fractal kinetics
  • Law of mass action
  • Macromolecular crowding

ASJC Scopus subject areas

  • Chemistry(all)

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