Re-irradiation of spinal cord compression due to metastasis in elderly patients

Dirk Rades, Jasmin N. Evers, Amira Bajrovic, Theo Veninga, Steven E. Schild

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aim: The present study investigated efficacy and toxicity of re-irradiation for an in-field recurrence of spinal cord compression due to metastasis (SCCM) in elderly patients. Patients and Methods: Data of 60 patients aged?65 years who were irradiated for an infield recurrence of SCCM were retrospectively analyzed. The fractionation regimen of re-irradiation and eight additional potential prognostic factors were evaluated for motor function. Results: Median time to in-field recurrence was 6 (2-45) months. After re-irradiation, 25 patients (42%) showed improvement of motor function, 28 (47%) no change, and 7 (12%) deterioration. No second in-field recurrences were observed. Post-treatment motor function was not associated with the fractionation regimen. Radiation myelopathy was not observed. The cumulative biologicallyeffective dose for myelopathy was 80-137 Gy2. Conclusion: Re-irradiation for in-field recurrences of SCCM in elderly patients appears safe and effective. Myelopathy appears unlikely, if the cumulative biologically effective dose is 137 Gy 2 or less. The fractionation regimen had no significant impact on motor function.

Original languageEnglish (US)
Pages (from-to)2555-2558
Number of pages4
JournalAnticancer Research
Volume34
Issue number5
StatePublished - May 1 2014

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Spinal Cord Compression
Neoplasm Metastasis
Spinal Cord Diseases
Recurrence
Re-Irradiation
Radiation

Keywords

  • Elderly patients
  • Fractionation
  • In-field recurrence
  • Re-irradiation
  • Spinal cord compression from metastatic cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Rades, D., Evers, J. N., Bajrovic, A., Veninga, T., & Schild, S. E. (2014). Re-irradiation of spinal cord compression due to metastasis in elderly patients. Anticancer Research, 34(5), 2555-2558.

Re-irradiation of spinal cord compression due to metastasis in elderly patients. / Rades, Dirk; Evers, Jasmin N.; Bajrovic, Amira; Veninga, Theo; Schild, Steven E.

In: Anticancer Research, Vol. 34, No. 5, 01.05.2014, p. 2555-2558.

Research output: Contribution to journalArticle

Rades, D, Evers, JN, Bajrovic, A, Veninga, T & Schild, SE 2014, 'Re-irradiation of spinal cord compression due to metastasis in elderly patients', Anticancer Research, vol. 34, no. 5, pp. 2555-2558.
Rades D, Evers JN, Bajrovic A, Veninga T, Schild SE. Re-irradiation of spinal cord compression due to metastasis in elderly patients. Anticancer Research. 2014 May 1;34(5):2555-2558.
Rades, Dirk ; Evers, Jasmin N. ; Bajrovic, Amira ; Veninga, Theo ; Schild, Steven E. / Re-irradiation of spinal cord compression due to metastasis in elderly patients. In: Anticancer Research. 2014 ; Vol. 34, No. 5. pp. 2555-2558.
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